Adding a certain compound to certain chemical reactions, such as: 626-95-9, 1,4-Pentanediol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks
To a solution of (rac)-pentane-l,4-diol (5.00 g) in DMF (53 mL) at 0 C was sequentially added imidazole (3.92 g) and feri-butyl(chloro)diphenylsilane (12 mL) and the mixture was stirred at room temperature for 22 h. The reaction was stopped by the addition of water and the mixture was extracted with hexanes. The combined organic layers were washed with saturated aqueous sodium chloride solution, dried and concentrated to yield the title compound (12.9 g). NMR (400 MHz, DMSO-i/6, 295 K) delta/ppm = 0.97 – 1.04 (m, 12H), 1.31 – 1.43 (m, 2H), 1.46 – 1.66 (m, 2H), 3.51 – 3.60 (m, 1H), 3.60 – 3.67 (m, 2H), 4.31 – 4.38 (m, 1H), 7.40 – 7.48 (m, 6H), 7.58 – 7.64 (m, 4H).
The synthetic route of 626-95-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; LUeCKING, Ulrich; HOG, Daniel; CHRIST, Clara; SACK, Ulrike; SIEGEL, Franziska; LIENAU, Philip; WERBECK, Nicolas; (170 pag.)WO2018/177889; (2018); A1;,
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