Reference of 144284-25-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 144284-25-3 as follows.
4.2 2,4,5-Trifluorobenzyliodide 3 2,4,5-Trifluorobenzylalcohol (2.26 g, 14 mmol) was dissolved in dry 1,4-dioxane (30 mL) and to that BF3·Et2O (1.98 g, 14 mmol) and KI (2.32 g, 14 mmol) were added and the resulting mixture was stirred for 48 h at room temperature. The reaction mixture was poured into cold water and extracted with diethyl ether. The combined organic layer was washed with water, brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The crude product was purified by column chromatography eluting with 10% ethyl acetate in hexane to give 3 (3.35 g, 88%) as a brown liquid. 1H NMR (400 MHz, CDCl3) delta 4.34 (s, 2H), 6.93-6.86 (m, 1H), 7.21-7.14 (m, 1H); 13C NMR (100 MHz, CDCl3) delta -5.78, 106.0, 106.2, 106.2, 106.4, 118.3, 118.5, 123.1, 145.7, 148.1, 148.7, 151.2, 154.2, 156.6.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,144284-25-3, its application will become more common.
Reference:
Article; Subbaiah; Haq, Wahajul; Tetrahedron Asymmetry; vol. 25; 13-14; (2014); p. 1026 – 1030;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts