Application of 2987-05-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2987-05-5, name is 4-(Methylamino)cyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.
Example 1 N-(4-bromo-2-fluorophenyl)-N’-(4-hydroxycyclohexyl)-N,N’-dimethylureaStep 1. 4-(methylamino)cyclohexanol hydrochloride; To a suspension of lithium tetrahydroaluminate (2.70 g, 0.0711 mol) in tetrahydrofuran (120.0 mL, 1.479 mol) was added tert-butyl (4-hydroxycyclohexyl)carbamate (3.00 g, 0.0139 mol). The reaction mixture was heated at reflux overnight. After cooling to rt, the mixture was carefully quenched with successively dropwise additions of water (2.70 mL, 0.150 mol), 3.750 M of sodium hydroxide in water (2.70 mL) (15%), and water (8.100 mL, 0.4496 mol). After stirring at rt for Ih, the mixture was filtered through a pad of Celite. The filtrate was dried with magnesium sulfate and evaporated to dryness. The crude material was used directly in next step. LCMS (M+H) 130.2. The crude amine was treated with 40 mL of 4 M HCl in dioxane solution at rt for 4 h, then evaporated to dryness to afford the corresponding HCl salt (2.16 g, 93.57%).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2987-05-5, 4-(Methylamino)cyclohexanol.
Reference:
Patent; INCYTE CORPORATION; WO2007/130898; (2007); A1;,
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