Application of 17366-48-2 ,Some common heterocyclic compound, 17366-48-2, molecular formula is C7H14ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: General Method F (copper catalyzed amination of aryl-hal) A microwave vial was charged with 1 ,4-diiodobenzene or l-bromo-4-iodobenzene (1.0 equiv), Cul (20 mol%), BINOL (20 mol%), and K3P04 (2 equiv.). The vial was capped and then evacuated and backfilled with Ar. Dialklyamine (1.2 equiv) and DMF were then added. The resulting mixture was stirred at rt for 2 to 4 d. The mixture was diluted with EtOAc, filtered through a cake of Celite and the filtrate was concentrated to give the crude product. Crude product was purified by flash chromatography to give the title compound.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17366-48-2, exo-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UNIVERSITY HEALTH NETWORK; LIU, Yong; LANG, Yunhui; NG, Grace; LI, Sze-Wan; PAULS, Heinz W.; LAUFER, Radoslaw; PATEL, Narendra Kumar B.; SAMPSON, Peter Brent; FEHER, Miklos; AWREY, Donald E.; WO2014/56083; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts