Adding a certain compound to certain chemical reactions, such as: 18202-10-3, Dodec-11-yn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 18202-10-3, blongs to alcohols-buliding-blocks compound. Recommanded Product: 18202-10-3
tert-Butyldiphenylsilyl chloride (TBDPSC1, 8.70 g, 31.65 mmol) was slowly added to a 0C solution of dodec-11-yn-1-ol (4.80 g, 26.37 mmol) and imidazole (3.23 g, 47.47 mmol) in anhydrous dichloromethane (100 mL). After stirring at room temperature for 3 h, the reaction mixture was washed with water (75 mL), brine (50 mL), and concentrated under reduced pressure. The residue was purified by SiO2 column chromatography using 3% EtOAc/hexanes as eluent to give 12-(tert-butyldiphenylsilyloxy)dodec-1-yne (9.75 g, 88%) as a colorless oil. TLC: 6% EtOAc/hexanes, Rf ? 0.7; 1H NMR (CDCl3, 300 MHz) delta 7.65-7.68 (m, 4H), 7.34-7.42 (m, 6H), 3.65 (t, J = 7.3 Hz, 2H), 2.18 (dt, J = 7.0, 2.4 Hz, 2H), 1.94 (t, J = 1.9 Hz, 1H), 1.20-1.60 (m, 16H), 1.04 (s, 9H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18202-10-3, its application will become more common.
Reference:
Patent; Max-Delbrueck-Centrum fuer Molekulare Medizin (MDC); EP2208720; (2010); A1;,
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