Related Products of 81335-87-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 81335-87-7 as follows.
Sub-1 (35.0g, 255.1mmol), 3,5-dimethylacetophenone (56.7g, 382.7mmol), tris (triphenylphosphine) ruthenium (II) dichloride (2mol%) And potassium hydroxide (15.7g, 280.7mmol) and toluene (300mL) were added to the reaction flask,Heat and stir to reflux, and separate water by condensing reflux trap. When the reaction is over, drop to room temperature and filter on a pad of silica gel. The product was further purified by column (eluent: n-hexane / ethyl acetate = 2/100), and finally the intermediate Sub-3 (35.3 g, yield 56%) was obtained by crystallization from isopropanol.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81335-87-7, its application will become more common.
Reference:
Patent; Zhejiang Huaxian Optoelectric Technology Co., Ltd.; Zheng Xianzhe; Zhao Xiaoyu; Hua Wanming; (31 pag.)CN110452271; (2019); A;,
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