Synthetic Route of 1051899-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1051899-73-0, name is (3-Amino-2-fluorophenyl)methanol, molecular formula is C7H8FNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Intermediate 102: ethyl [2-fluoro-3-(hydroxymethyl)phenyl]carbamate A stirred suspension of sodium carbonate (78 mg, 1.573 mmol) and Intermediate 101 (222 mg, 1.573 mmol) in 10 mL of water was cooled at 0 C. under nitrogen atmosphere. Ethyl chlorocarbonate (ALDRICH, 171 mg, 1.573 mmol) was added dropwise. Reaction was stirred for 1 h 30 min at 0 C. and then allowed to reach room temperature. Crude of reaction was partitioned with Et2O. Organic layers were dried with MgSO4 (anh), filtered and concentrated to obtain the title compound (359 mg, 1.600 mmol, quantitative yield). 1H NMR (300 MHz, DMSO-d6) 8 ppm: 9.21 (br s, 1H), 7.45-7.55 (m, 1H), 7.05-7.22 (m, 2H), 5.24 (br s, 1H), 4.51 (s, 2H), 4.10 (q, 2H), 1.22 (t, 3H). [ES+MS] m/z 214 (MH+).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1051899-73-0, (3-Amino-2-fluorophenyl)methanol.
Reference:
Patent; Ballell Pages, Lluis; Castro Pichel, Julia; Fernandez Menendez, Raquel; Fernandez Velando, Esther Pilar; Gonzalez Del Valle, Silvia; Leon Diaz, Maria Luisa; Mendoza Losana, Alfonso; Wolfendale, Matthew James; US2012/95064; (2012); A1;,
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