Synthetic Route of 13651-14-4, Adding some certain compound to certain chemical reactions, such as: 13651-14-4, name is (2,3-Dimethylphenyl)methanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13651-14-4.
Compound M (0.040 g) obtained in Reference Example 13 and 2,3-dimethylbenzyl alcohol (0.11 g) were dissolved in tetrahydrofuran (0.50 mL). Triphenylphosphine (0.21 g) and diethyl azodicarboxylate (0.12 mL) were added thereto under ice-cooling, followed by stirring at room temperature for 12 hours. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel preparative thin layer chromatography (hexane:ethyl acetate_triethylamine=5:10:1) to give Compound 14 (0.016 g, 32%) as a pale yellow oily substance. [0315] 1H NMR (270 MHz, CDCl3) delta7.50-7.38 (2H, m), 7.30-6.94 (5H, m), 4.96 (1H, septet), 4.86-4.66 (2H, m), 3.88-3.50 (6H, m), 3.38-3.22 (2H, m), 2.52 (4H, m), 2.46-2.30 (2H, m), 2.29 (3H, s), 2.17 (3H, s), 1.68 (4H, m), 1.49 (2H, m), 1.07 (6H, d). [0316] MASS (m/e) 539 [(M+H)+]
According to the analysis of related databases, 13651-14-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Millennium Pharmaceuticals, Inc.; Kyowa Hakko Kogyo Co., Ltd.; US2003/225288; (2003); A1;,
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