Reference of 14426-21-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14426-21-2, name is Diethanolamine hydrochloride, molecular formula is C4H12ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirring solution of 57 (500 mg, 3.33 mmol) in DCM (100 mL) was added CSI (290 tL, 471 mg, 3.33 mmol). After 20 mi Et3N (1.4 mL, 1.0 g, 10 mmol) and a solution of diethanolamine.HC1 (571 mg, 4.0 mmol) in DMF (5 mL) were added subsequently. After an additional 45 mm., the reaction mixture was concentrated under reduced pressure and the residue was purified by gradient column chromatography (0 -* 15% MeOH in DCM).Product 66 was obtained as colorless thick oil (767 mg, 2.13 mmol, 64%). ?H NIVIR (400IVIFIz, CDC13) (ppm) 4.26 (d, J= 8.2 Hz, 2H), 3.87 (t, J= 4.9 Hz, 4H), 3.55 (t, J = 4.9Hz, 4H), 2.37-2.16 (m, 6H), 1.65-1.45 (m, 2H), 1.39 (quintet, J = 8.6 Hz, 1H), 1.05-0.92 (m, 2H)
According to the analysis of related databases, 14426-21-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SYNAFFIX B.V.; VERKADE, Jorge Merijn Mathieu; WIJDEVEN, Maria Antonia; VAN DE SANDE, Petrus Josephus Jacobus Maria; VAN BERKEL, Sander Sebastiaan; VAN DELFT, Floris Louis; (150 pag.)WO2016/53107; (2016); A1;,
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