Application of 17366-48-2 , The common heterocyclic compound, 17366-48-2, name is exo-8-Azabicyclo[3.2.1]octan-3-ol hydrochloride, molecular formula is C7H14ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
8-Aza-bicyclo [3.2. 1] octanol hydrochloride (5.1 g, 31.45 mmol)) and sodium carbonate (13.3 g, 125.8 mmol) are suspended in 150 mi of ethanol at room temperature. 2-Bromo- ethanol (4.4 ml, 62.9 mmol) is added dropwise within 20 minutes and the reaction mixture is refluxed for 15 hours. After cooling to room temperature the reaction mixture is evaporated under reduced pressure. The mixture is stirred with 200 ml of DCM and filtered. The clear filtrate is dried over anhydrous sodium sulfate, filtered, evaporated under reduced pressure und dried at high vacuum. Yield : 5.4 g (100%) of a colorless oil. MS (ESI) : 172 [M+H] +, 1 H-NMR (DMSO-d6) : 5 (ppm) 4.25 (d, 2H), 3.78 (t, 1H), 3.42 (t, 2H), 3.06 (m, 2H), 2.36 (t, 2H), 2.03 (m, 2H), 1.85 (m, 2H), 1.75 (m, 2H), 1. 55 (d, 2H).
The synthetic route of 17366-48-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2005/77932; (2005); A2;,
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