Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 431-23-2, name is 3,3,3-Trifluoro-2-methylpropan-1-ol. A new synthetic method of this compound is introduced below., COA of Formula: C4H7F3O
To a solution of 3,3,3-trifluoro-2-methylpropan-1-ol (800 mg, 6.25 mmol) in DCM (20 mL) was added triethylamine (950 mg, 9.39 mmol).The reaction mixture was cooled to -20 C,Then trifluoromethanesulfonic anhydride (2.20 g, 7.70 mmol) was added to the above system.The reaction was stirred at 0 & lt; 0 & gt; C overnight.The reaction mixture was diluted with DCM (50 mL)And then washed with 1 M aqueous hydrochloric acid (50 mL x 2)The separated organic phases were dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound as a yellow oil(1.1 g, 68% yield).
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Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; Xi, Ning; Dai, Weilong; Li, Minxiong; Chen, Wuhong; Zhang, Tao; Hu, Haiyang; Li, Xiaobo; Liu, Jun; Wang, Tingjin; (146 pag.)CN106478651; (2017); A;,
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