Adding a certain compound to certain chemical reactions, such as: 21285-46-1, (E)-2,3-Dibromobut-2-ene-1,4-diol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: (E)-2,3-Dibromobut-2-ene-1,4-diol, blongs to alcohols-buliding-blocks compound. Recommanded Product: (E)-2,3-Dibromobut-2-ene-1,4-diol
10128] Propargyl bromide (80% solution in toluene, 1.25 mE, 11.6 mmol, 1 equiv) was added to a stirred solution of (E)-2,3-dibromobut-2-ene-1,4-diol (51, 8.56 g, 34.8 mmol, 3.00 equiv) and potassium hydroxide (1.30 g, 23.2 mmol,2.00 equiv) in 50% N,N-dimethylformamide-water (30 mE) at 24 C. The resulting mixture was stirred for 12 hat 24 C. The product mixture was purified by flash-column chromatography (eluting with 25% ethyl acetate-hexanes, grading to 100% ethyl acetate, one step) to afford (E)-2,3-dibromo-4- (prop-2-yn-1-yloxy)but-2-en-1-ol (S2) as a white solid (2.69 g, 82%). R1=0.26 (20% ethyl acetate-hexanes; CAM). ?H NMR (400 MHz, CDC13): oe 4.49 (s, 4H, H,/H2), 4.14 (d, 2H, J=2.4 Hz, H3), 3.28 (t, 1H, J=6.8 Hz, OH), 2.49 (t, 1H, J=2.4 Hz, H4). ?3C NMR (600 MHz, CDC13): oe 125.3 (C), 118.6 (C), 78.8 (C), 75.5 (CH), 72.8 (CH2), 66.8 (CH2), 57.2 (CH2). IR (NaC1), cm?: 3295 (br), 1092 (m), 642 (m). HRMS-ESI (m/z): [M+H] calculated for C7H8798?Br2O2, 283.8871. found, 283.8878.
The synthetic route of 21285-46-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; The Regents of the University of California; Bertozzi, Carolyn R.; Woo, Christina; (50 pag.)US2016/187350; (2016); A1;,
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