Reference of 125617-18-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 125617-18-7, name is (E)-3-(4-(Trifluoromethyl)phenyl)prop-2-en-1-ol. This compound has unique chemical properties. The synthetic route is as follows.
(2E)-3-[4-(Trifluoromethyl)phenyl]-2-propen-1-ol (242 mg), methyl 3-(2-aminophenoxy)benzoate (243 mg), triphenyl phosphine (11 mg) and molecular sieves 4A (200 mg) were suspended in benzene (5 mL) under an argon atmosphere. Titanium (IV) isopropoxide (150 muL) and palladium acetate (6 mg) were added to the suspension and heated to reflux for 3 hours. The reaction mixture was cooled down to room temperature, 1N hydrochloric acid was added thereto and the mixture was extracted with ethyl acetate. 1N Sodium hydroxide was added to the aqueous layer to make alkaline and the mixture was extracted with ethyl acetate again. The organic layers were combined, successively washed with water and saturated saline solution, dried over anhydrous sodium sulfate and concentrated. The resulting residue was purified by a silica gel column chromatography (hexane : ethyl acetate = 20:1) to give methyl ester of the title compound (methyl 3-[2-({(2E)-3-[4-(trifluoromethyl)phenyl]-2-propenyl}amino)phenoxy]benzoate). The same operation as Example 4 was carried out using the methyl ester of the title compound instead of the compound produced in Example 3 to give the compound of the present invention (232 mg) having the following properties. TLC: Rf 0.35 (dichloromethane:methanol = 19:1); NMR (DMSO-d6) delta 3.95, 5.68, 6.41-6.55, 6.56-6.65, 6.75, 6.89, 6.99-7.09, 7.19-7.30, 7.38, 7.47, 7.55, 7.59-7.67, 13.06.
According to the analysis of related databases, 125617-18-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1661879; (2006); A1;,
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