Reference of 1013031-65-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1013031-65-6 as follows.
To a solution of (2,6-dibromophenyl)methanol (5 g, 18.8 mmol) in dichloromethane (50 mL) was added te^butylchlorodimethylsilane (4.25 g, 28.2 mmol) and lH-imidazole (1.91 g, 28.2 mmol) at 0 C. The reaction was stirred at ambient temperature for 16 h. Upon completion, the mixture was washed with water (3 x 100 mL), the organic layer was dried over Na2S04. The organic layer was filtered and concentrated to dryness. Purification by column chromatography (PE) gave the product (7 g, yield: 95%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1013031-65-6, its application will become more common.
Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; BOWEN, Carrie, A.; BURDI, Douglas, F.; HEFFERNAN, Michele, L., R.; HERMAN, Lee, W.; XIE, Linghong; (266 pag.)WO2019/28165; (2019); A1;,
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