Application of 144284-25-3, Adding some certain compound to certain chemical reactions, such as: 144284-25-3, name is 2,4,5-Trifluorobenzyl alcohol,molecular formula is C7H5F3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 144284-25-3.
To 25mL sealed tube were added norcantharidin 4 (1.0mmol, 168mg), 4-DMAP (1.0mmol, 244mg), after argon replacement three times, then added DCM 2.5mL, 2,4,5-trifluoro Benzyl alcohol 5 (2.0mmol, 232muL) was reacted at 60 for 14h. After the reaction was completed, it was cooled to room temperature, washed three times with HCl (1 mol/L) and saturated brine, and the organic phases were combined. After the organic phases were dried over anhydrous sodium sulfate, flash column chromatography gave a white solid product 6-3, yield 37.9%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 144284-25-3, 2,4,5-Trifluorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Zunyi Medical University; Jia Jia; He Chunyang; Zhu Erlin; Wang Le; Li Xiaofei; Zhang Jianyong; (9 pag.)CN111253415; (2020); A;,
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