Adding a certain compound to certain chemical reactions, such as: 666747-06-4, (2,4-Dibromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6Br2O, blongs to alcohols-buliding-blocks compound. Formula: C7H6Br2O
To a stirred solution of commercially available 2,4-dibromobenzyl alcohol SI-i(500 mg, 1.88 mmol) in DMF (4 mL), under inert atmosphere, were added imidazole(153 mg, 2.25 mmol, i.2 eq.) and TBSC1 (340 mg, 2.25 mmol, 1.2 eq.). The resultingmixture was stirred for 12 h, then hydrolyzed with water and extracted with a mixture9:1 cyclohexane/CH2C12 (three times). The combined organic extracts were washed withwater, brine, dried over Mg504, filtered and concentrated under reduced pressure. The cmde product was then purified by chromatography (100percent petroleum ether) to afford the title compound SI-2 (638 mg, 1.68 mmol, 89percent) as a colorless oil.?H NMR (CDC13, 300 MHz): 7.66 (d, J = 1.8 Hz, 1H), 7.49-7.42 (m, 2H), 4.67 (s, 2H), 0.97 (s, 9H), 0.14 (s, 6H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,666747-06-4, (2,4-Dibromophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE BORDEAUX; UNIVERSITE DE RENNES 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; WODRICH, Harald; CHEVET, Eric; VAN DE WEGHE, Pierre; (73 pag.)WO2018/178167; (2018); A1;,
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