Related Products of 41570-61-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41570-61-0, name is 2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol, molecular formula is C12H18ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Compound 1, 1.8 g (7.9 mmol), was dissolved in 30 mL of diethyl ether, 0.9 mL (7.9 mmol) of a 8.5 M solution of HCl in propan-2-ol was added, and the precipitate was filtered off, washed with diethyl ether, and dried over phosphoric anhydride. Yield 1.9 g (91%), white crystals, mp 165-167C. 1H NMR spectrum (DMSO-d6), delta, ppm: 1.31 s (9H, t-Bu), 2.70 d (1H, CH2, J = 12.3 Hz), 3.07 d (1H,CH2, J = 12.4 Hz), 5.31 d (1H, CH, J = 10.1 Hz), 6.37 s(1H, OH), 7.37 d.d (1H, Harom, J = 7.3, 1.5 Hz), 7.41-7.49 m (2H, Harom), 7.69 d (1H, Harom, J = 8.8 Hz),8.64 br.s (1H, NH), 9.20 br.s (1H, NH). 13C NMR spectrum(DMSO-d6), deltaC, ppm: 25.4 [(CH3)3C], 47.1[C(CH3)3], 57.0 (CH2), 66.3 (CHOH), 128.0 (C4?, C5?),128.5 (C3?), 129.7 (C6?), 131.4 (C2?), 139.5 (C1?). Lowresolutionmass spectrum: m/z: 228.23 [M + H]+. Highresolutionmass spectrum: m/z 228.11490 [M + H]+.Mass spectrum (EI), m/z: 141 [M – CH2=NHC(CH3)3]+,86 [CH2=NHC(CH3)3]+.f
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 41570-61-0, 2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol.
Reference:
Article; Burdeinyi, M. L.; Glushkova, M. A.; Popkov, S. V.; Russian Journal of Organic Chemistry; vol. 56; 3; (2020); p. 390 – 394; Zh. Org. Khim.; vol. 56; 3; (2020); p. 379 – 383,5;,
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