Reference of 666747-06-4, Adding some certain compound to certain chemical reactions, such as: 666747-06-4, name is (2,4-Dibromophenyl)methanol,molecular formula is C7H6Br2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 666747-06-4.
Step 2:Synthesis of 2,4-dibromo-1-(1-methoxy-1-methylethoxymethyl)benzeneUnder a nitrogen atmosphere, to a solution of 2,4-dibromobenzyl alcohol (40 g, 0.15 mol) in tetrahydrofuran (300 ml) was added 2-methoxypropene (144 ml, 1.5 mol) at room temperature, and then the mixture was cooled to 0°C.At the same temperature, pyridinium p-toluenesulfonic acid (75 mg, 0.30 mmol) was added and the mixture was stirred for 1 hour.The reaction mixture was poured into a saturated aqueous solution of sodium hydrogen carbonate cooled to 0°C, and extracted with toluene.The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the titled compound as an oil in quantitative yield.The product was used in the next step without further purification.1H-NMR (CDCl3) delta: 1.44 (6H, s), 3.22 (3H, s), 4.48 (2H, s), 7.42 (1H, d, J=8.0Hz), 7.44 (1H, dd, J=1.5, 8.0Hz), 7.68 (1H, d, J=1.5Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 666747-06-4, (2,4-Dibromophenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chugai Seiyaku Kabushiki Kaisha; EP2308886; (2011); A1;,
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