Month: February 2022

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate. A new synthetic method of this compound is introduced below., SDS of cas: 55357-38-5

40 mg of {2-[(4′-Hexyl-biphenyl-4-carbonyl)-amino]-benzyl}-phosphonic acid (compound of preparation example 3) are dissolved in 10 ml of pyridine and 111 mg of dry choline p- toluolsulfonate salt and 2 ml trichloroacetonitrile are added. The mixture obtained is stirred at 500C for 76 hours. From the mixture obtained solvent is evaporated and the evaporation residue is subjected to RP-18 chromatography (0,1% TFA-water/methanol gradient). [2-({2- [(4′-Hexyl-biphenyl-4-carbonyl)-amino]-be?zyl}-hydroxy-phosphinoyloxy)-ethyl]-trimethyl- ammonium, inner salt is obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55357-38-5, 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate.

Reference:
Patent; NOVARTIS AG; WO2008/22771; (2008); A1;,
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Related Products of 1875-89-4, Adding some certain compound to certain chemical reactions, such as: 1875-89-4, name is 2-(m-Tolyl)ethanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1875-89-4.

Example 3:; 3-(lH-Indol-2-ylV4-(2-m-tolyl-ethoxyMH-pyridin-2-one; a) 2-[2-Methoxy-4-(2-m-tolyl-ethoxy)-pyridin-3-yl]-lH-indole; A mixture of 2-(4-iodo-2-methoxy-pyridin-3-yl)-lH-indole (20 mg, 57 mumol), copper iodide (1.09 mg, 5.7 mumol), 1,10-phenanthroline (2.0 mg, 11.4 mumol) and cesium carbonate (37 mg, 11.4 mumol) are suspended in 2-m-tolylethanol (85 mul, 0.62 mmol) under inert gas atmosphere in a sealed tube which is heated at 110 0C for 24 hours. The reaction mixture is treated with ethyl acetate (10 ml), water (10 ml) and cone, aqueous ammonia (100 mul). The phases are separated, worked up and extracted with ethyl acetate. The product is purified by preparative chromatography. Yield: 10 mg (47 percent).1H-NMR (400 MHz, D6-DMSO): delta= 10.82 (br, IH), 8.05 (d, IH), 7.49 (d, IH), 7.42 (d, IH), 7.15 – 7.05 (m, 4H), 7.01 – 6.94 (m, 3H), 6.67 (s, IH), 4.37 (t, 2H), 3.93 (s, 3H), 3.05 (t, 2H), 2.16 (s, 3H)MS: M = 359.12 (ESI+)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1875-89-4, 2-(m-Tolyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/25526; (2008); A1;,
Alcohol – Wikipedia,
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Reference of 59012-91-8, Adding some certain compound to certain chemical reactions, such as: 59012-91-8, name is 4-(Hydroxymethyl)phenyl pivalate,molecular formula is C12H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59012-91-8.

Compound M2. [00202] Compound Ml (see below; 7.79 g, 37.4 mmol) was dissolved in anhydrous THF (50 mL) containing N,N-diisopropylethylamine (8.14 mL, 46.8 mmol) under argon, and the resulting solution was chilled down to 0C in an ice-water bath. Diisopropylphosphoramidous dichloride (3.46 mL, 18.8 mmol) was added drop wise via syringe over a period of 5 minutes with stirring and cooling. The reaction mixture was allowed to warm up to room temperature and stirred overnight. Precipitated salts were removed by filtration, and the filtrate was concentrated in vacuum. The residue was dissolved in ethyl acetate (-150 mL) and washed with 5% NaHC03 (3 x 50 mL) followed by brine (50 mL). The organic layer was separated, dried over Na2S04, filtered and concentrated. The product (TLC: Rf -0.6 in ethyl acetate/hexanes/triethylamine (20:80:2)) was isolated using flash chromatography on silica gel column (4 x 20 cm) loading from hexanes/ triethylamine (100:2) and eluting with acetate/hexanes/ triethylamine (20:80:2). Pure fractions were pooled and concentrated to give 8.1 g (79%) of colorless oil. XH NMR (DMSO-d6): delta 7.37 (d, 4H, J=8.6 Hz), 7.07 (d, 4H, J=8.6 Hz), 4.76 – 4.63 (m, 4H), 3.70 – 3.61 (m, 2H), 1.30 (s, 18H), 1.16 (d, 12H, J=6.8 Hz). 31P NMR (DMSO-d6): delta 147.30.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 59012-91-8, 4-(Hydroxymethyl)phenyl pivalate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CEPHEID; GALL, Alexander A.; LOKHOV, Sergey G.; PODYMINOGIN, Mikhail A.; VIAZOVKINA, Ekaterina V.; LUND, Kevin Patrick; WO2015/153510; (2015); A1;,
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Reference of 54410-90-1 ,Some common heterocyclic compound, 54410-90-1, molecular formula is C11H22O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The compound (T-19) (5.00 g), the compound (T-18) (8.29 g), DMAP (1.0 g) and methylene chloride (80 ml) were placed in a reactor and cooled to 0 C.A solution of DCC (5.00 g) in dichloromethane (40 ml) was slowly added dropwise thereto, returned to room temperature and stirred for 12 hours.After the insolubles were separated, the reaction mixture was poured into water and the aqueous layer was extracted with dichloromethane.The organic layer formed simultaneously with water washing was dried over anhydrous magnesium sulfate.The solution was concentrated under reduced pressure and the residue was purified by silica gel chromatography (volume ratio, heptane: toluene = 1: 1) to obtain compound (T-20) (8.66 g; 75%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 54410-90-1, 4-Pentylcyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jieenzhi Co., Ltd.; Jieenzhi Petrochemical Co., Ltd.; Tian Zhongyuzhi; Shi Yekuangyi; Jin Tengshishang; Di Tianhekuan; (145 pag.)CN107108457; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 624-08-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 624-08-8, name is Heptadecan-9-ol, molecular formula is C17H36O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

From 0 C in a round flask was added the p- toluenesulfonyl chloride (5.5g) and the mixture was stirred and then placed in methylene chloride (150mL). Put Then, hepta-decane-9-ol followed by the addition of (5g) and slowly diluted in methylene chloride (5mL), triethylamine (7mL) and triethylamine hydrochloride (3.71g), and the mixture was stirred for 90 minutes . MC and the organic layer with brineAnd then extracted to remove the remaining water over anhydrous magnesium sulfate, and after evaporation of the solvent was recrystallized from a MC and MeOH to give the Heptadecane-9-yl 4-methlybenzenesulfornate (compound f-4) as a white solid (yield: 64% ).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 624-08-8, Heptadecan-9-ol.

Reference:
Patent; Pusan National University Industry-Academic Cooperation Foundation; Hwang, Do Hun; Kim, Ji Hun; Kim, Hee Woon; Im, Jong Min; (52 pag.)KR101495152; (2015); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 13651-14-4 , The common heterocyclic compound, 13651-14-4, name is (2,3-Dimethylphenyl)methanol, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture containing benzyl alcohol(1 mmol), beta-naphthol (1 mmol), 4-hydroxycoumarin(1 mmol), 4 mmol % of [BDBDMIm]Br, and 0.05 g of CAN was stirred at room temperature for the requiredreaction times. Progress of the reaction was monitoredby TLC (EtOAc : petroleum ether, 1 : 3). Uponcompletion of the process the product was extractedwith CHCl3/H2O. The organic phases was separatedand the solvent evaporated. Crystallization of theresidue gave the pure product. The aqueous phase wasconcentrated under reduced pressure, washed withEt2O, and evaporated under reduced pressure torecover the ionic liquid for subsequent use.

The synthetic route of 13651-14-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gharib; Nikpassand; Russian Journal of General Chemistry; vol. 86; 12; (2016); p. 2759 – 2767; Zh. Obshch. Khim.; vol. 86; (2016); p. 2759 – 2767,9;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 41570-61-0, 2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 41570-61-0, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C12H18ClNO

Tulobuterol (1.00 g) and Boc-beta-alanine (0.99 g) were dissolved in dichloromethane (10 mL). After cooling to 0 C., N,N-dimethylaminopyridine (161.3 mg) and water soluble carbodiimide (1.11 g) were added thereto followed by stirring for 3 hours at room temperature. After confirming the disappearance of the reacting materials by thin layer chromatography, a saturated aqueous solution of ammonium chloride was added to terminate the reaction. After dilution with ethyl acetate, the organic layer was washed with a saturated aqueous solution of ammonium chloride, a saturated aqueous solution of sodium hydrogen carbonate, and saturated brine. After drying over magnesium sulfate anhydrous, it was filtered and the solvent was distilled off under reduced pressure to obtain the desired compound 42 (1.71 g, 98%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41570-61-0, its application will become more common.

Reference:
Patent; SEIKAGAKU CORPORATION; Sato, Tomoya; Takeuchi, Hisayuki; Zuinen, Ryoji; (39 pag.)US2016/158369; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 1875-89-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1875-89-4, name is 2-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 97 5-{(2R)-2-[(2R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid bis-(2-m-tolyl-ethyl) ester hydrochloride salt The title compound was prepared as a brown oil from 5-{2-[2-(3-chloro-phenyl)-2-hydroxy-ethylamino]-propyl}-benzo[1,3]dioxole-2,2-dicarboxylic acid and 2-(3-methylphenyl)ethanol according to the procedure of Example 1; yield: 81percent; 1 H NMR (300 MHz, CDCl3): delta 1.12 (m, J=6.3 Hz, 3H),2.27 (s, 6H), 2.79 (m, 7H), 3.19 (m, 1H), 3.48 (m, 2H), 4.29 (m, J=6.6 Hz, 4H), 5.49 (m, 1H,) 6.75 (m, J=8.1 Hz, 1H), 6.83 (m, 1H), 7.05 (m, 8H), 7.20 (m, 1H), 7.27 (m, 1H), 7.43 (s, 1H), 7.5 (m, 2H); MS (ES) m/z (relative intensity): 658 (M+ +H, 100).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1875-89-4, 2-(m-Tolyl)ethanol.

Reference:
Patent; American Home Products Corporation; US5914339; (1999); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 92409-15-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 92409-15-9, name is 2-(2-Methoxyphenoxy)-1-(4-methoxyphenyl)propane-1,3-diol, molecular formula is C17H20O5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In 5 ml of quartz optical reaction tube, adding 0.05 mmol 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)-1,3-propanediol, 5 mg mpg-C3N4Catalyst, magneton, and add 1 ml solvent acetonitrile (substrate concentration is 0.05 mol/L). Air above the oxygen displacement reaction tube, and the opening is sealed, is arranged in the integrated light in the reaction device, the rotating speed of 500 r/min, the illumination wavelength is 405 nm (the power of 6 W), temperature constant at 40C, reaction 8 h. After the reaction, gas chromatography – mass spectrum detecting the product, and for high performance liquid chromatography quantitative, substrate conversion and product yield is shown in table 1.

According to the analysis of related databases, 92409-15-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dalian Institute of Chemical Physics; Wang Feng; Liu Huifang; Wang Min; Li Hongji; Luo Nengchao; Su Kaiyi; (14 pag.)CN109456160; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 18385-82-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18385-82-5, name is 7-Bromochroman-4-ol. This compound has unique chemical properties. The synthetic route is as follows.

7-bromochaoman-4-ol (8.80 mmol, crude), TBSCl (1.64 g, 10.5 mmol), and imidazole (1.80 g, 26.4 mmol) were stirred in DCM (17 mL) at r.t. After 16h the reaction was quenched by the addition of water (100 mL) and DCM (100 mL). The organic layer was removed and the aqueous layer was extracted with DCM (2 x 100 mL). The combined organic fractions were dried with Na2SO4 and concentrated. The crude product was purified by column chromatography to provide ((7-bromochroman-4-yl)oxy)(tert-butyl)dimethylsilane (2.9 g, 96%). mlz 375.0 [M+MeOH+H]+, 1H NMR (400 MHz, Chloroform-d) 7.05 (d, J = 8.0 Hz, 1H), 7.02 – 6.94 (m, 2H), 4.74 (t, J = 4.6Hz, 1H), 4.31 (ddd, J 10.9, 9.6, 3.0 Hz, 1H), 4.20 (ddd, J = 10.9, 5.7, 3.6 Hz, 1H), 2.11 – 1.88 (m,2H), 0.90 (s, 9H), 0.15 (s, 3H), 0.13 (s, 3H).

According to the analysis of related databases, 18385-82-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; BERGERON, Phillipe; BURFORD, Kristen; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; FOCKEN, Thilo; GRIMWOOD, Michael Edward; HASAN, Abid; LAI, Kwong Wah; LIU, Zhiguo; MCKERRALL, Steven; NGUYEN, Teresa Phuongtram; SAFINA, Brian; SUTHERLIN, Daniel; TAN, Wang Tao; (470 pag.)WO2017/58821; (2017); A1;,
Alcohol – Wikipedia,
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