Application of 55357-38-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, molecular formula is C12H21NO4S, molecular weight is 275.3644, as common compound, the synthetic route is as follows.
EXAMPLE 9 A solution of 2.22 g of (E)-stigmasta-5,22-dien-3beta-yl (2-hydroxyethyl)carbonate and 1.1 ml of pyridine in 10 ml of chloroform is added dropwise to a solution, cooled to 0 C., of 0.75 g of phosphorus oxychloride in 3 ml of chloroform. The mixture is reacted at room temperature for 1 hour. Then, 1.6 g of choline tosylate in 15 ml of pyridine are added. The mixture is stirred overnight, then a solution of 2 g of potassium bicarbonate is added. The mixture is evaporated to dryness and the residue is taken up in 100 ml of THF/methanol/chloroform (1/1/1). The solids are filtered off. The solution remaining behind is percolated over an ion exchanger (Amberlite MB-3). After chromatography on silica gel with chloroform/methanol/water (60/35/5 vol) and crystallization from methylene chloride/acetone there are obtained 1.6 g of O-[hydroxy-[2-[[[(E)-stigmasta-5,22-dien-3beta-yloxy]carbonyl]oxy]ethoxy]phosphinyl]choline hydroxide internal salt, MS: 666 (M+H+).
The chemical industry reduces the impact on the environment during synthesis 55357-38-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Hoffmann-La Roche Inc.; US5215972; (1993); A;,
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