Related Products of 18385-82-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 18385-82-5, name is 7-Bromochroman-4-ol. This compound has unique chemical properties. The synthetic route is as follows.
7-bromochaoman-4-ol (8.80 mmol, crude), TBSCl (1.64 g, 10.5 mmol), and imidazole (1.80 g, 26.4 mmol) were stirred in DCM (17 mL) at r.t. After 16h the reaction was quenched by the addition of water (100 mL) and DCM (100 mL). The organic layer was removed and the aqueous layer was extracted with DCM (2 x 100 mL). The combined organic fractions were dried with Na2SO4 and concentrated. The crude product was purified by column chromatography to provide ((7-bromochroman-4-yl)oxy)(tert-butyl)dimethylsilane (2.9 g, 96%). mlz 375.0 [M+MeOH+H]+, 1H NMR (400 MHz, Chloroform-d) 7.05 (d, J = 8.0 Hz, 1H), 7.02 – 6.94 (m, 2H), 4.74 (t, J = 4.6Hz, 1H), 4.31 (ddd, J 10.9, 9.6, 3.0 Hz, 1H), 4.20 (ddd, J = 10.9, 5.7, 3.6 Hz, 1H), 2.11 – 1.88 (m,2H), 0.90 (s, 9H), 0.15 (s, 3H), 0.13 (s, 3H).
According to the analysis of related databases, 18385-82-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; BERGERON, Phillipe; BURFORD, Kristen; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; FOCKEN, Thilo; GRIMWOOD, Michael Edward; HASAN, Abid; LAI, Kwong Wah; LIU, Zhiguo; MCKERRALL, Steven; NGUYEN, Teresa Phuongtram; SAFINA, Brian; SUTHERLIN, Daniel; TAN, Wang Tao; (470 pag.)WO2017/58821; (2017); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts