Adding a certain compound to certain chemical reactions, such as: 17102-63-5, 4-Bromo-2-methoxybenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H9BrO2, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H9BrO2
Step 2:; To the benzyl alcohol prepared in step 1 (0.86 g, 4.0 mmol) in DMF (8 mL) was added CuCN (1.1 g, 12 mmol). The mixture was warmed to 15O°C and stirred for 20 h. The mixture was then cooled to room temperature and EtOAc was added, followed by a saturated NH4CI/NH4OH solution. The mixture was stirred vigorously for 10 minutes and extracted with EtOAc, then the organic layer was dried (MgSO4), filtered, and concentrated in vacuo. Purification by silica gel chromatography provided 4-hydroxymethyl-3-methoxy-benzonitrile (0.38 g, 2.3 mmol).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,17102-63-5, 4-Bromo-2-methoxybenzyl alcohol, and friends who are interested can also refer to it.
Reference:
Patent; SCHERING CORPORATION; WO2006/60461; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts