In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 431-23-2, name is 3,3,3-Trifluoro-2-methylpropan-1-ol, the common compound, a new synthetic route is introduced below. Recommanded Product: 431-23-2
Iodine (44.58 g, 175.6 mmol) was added in five portions to a stirring solution of (S*)-3,3,3-trifluoro-2-methylpropan-1-ol (15.0 g, 117 mmol, Intermediate 89), PPh3 (46.07 g, 175.6 mmol) and imidazole (11.96 g, 175.7 mmol) in NMP (75 mL) at a rate that maintained the internal temperature between 40 and 50 C. The mixture was then warmed to 55-60 C. and stirred until the reaction went to completion. The reaction mixture was then distilled directly to afford the title compound as a solution in NMP (50.5% w/w, bp 50-65 C. at 1-2 mm Hg).
The synthetic route of 431-23-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Janssen Pharmaceutica NV; Goldberg, Steven; Martin, Connor L.; Fennema, Elizabeth G.; Kummer, David A.; Nishimura, Rachel T.; Woods, Craig R.; Wolin, Ronald L.; Jones, William M.; Fourie, Anne M.; Xue, Xiaohua; (180 pag.)US2019/382349; (2019); A1;,
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