Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 57371-44-5, name is 3-(4-(Benzyloxy)-3-methoxyphenyl)propan-1-ol. A new synthetic method of this compound is introduced below., Formula: C17H20O3
General procedure: To an ice-cooled solution of 2-iodoxybenzoic acid (0.876 g, 3.129 mmol) in DMSO (1.11 mL, 15.64 mmol) was added a solution of alcohol 26a (0.59 g, 2.607 mmol) in dry CH2Cl2 (10 mL). The mixture was stirred at room temperature for 2 h and then filtered through a Celite pad and washed with ether. The combined organic filtrates were washed with water, brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/pet-ether, 1:9) to afford the pure compound 27a (0.508 g, 87%) as a viscous liquid. The unstable aldehyde used immediately for the next reaction.
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Reference:
Article; Sabitha, Gowravaram; Srinivas, Chitti; Reddy, Teega Rammohan; Yadagiri, Kurra; Yadav, Jhillu Singh; Tetrahedron Asymmetry; vol. 22; 24; (2011); p. 2124 – 2133;,
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