Related Products of 1875-89-4, Adding some certain compound to certain chemical reactions, such as: 1875-89-4, name is 2-(m-Tolyl)ethanol,molecular formula is C9H12O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1875-89-4.
Example 3:; 3-(lH-Indol-2-ylV4-(2-m-tolyl-ethoxyMH-pyridin-2-one; a) 2-[2-Methoxy-4-(2-m-tolyl-ethoxy)-pyridin-3-yl]-lH-indole; A mixture of 2-(4-iodo-2-methoxy-pyridin-3-yl)-lH-indole (20 mg, 57 mumol), copper iodide (1.09 mg, 5.7 mumol), 1,10-phenanthroline (2.0 mg, 11.4 mumol) and cesium carbonate (37 mg, 11.4 mumol) are suspended in 2-m-tolylethanol (85 mul, 0.62 mmol) under inert gas atmosphere in a sealed tube which is heated at 110 0C for 24 hours. The reaction mixture is treated with ethyl acetate (10 ml), water (10 ml) and cone, aqueous ammonia (100 mul). The phases are separated, worked up and extracted with ethyl acetate. The product is purified by preparative chromatography. Yield: 10 mg (47 percent).1H-NMR (400 MHz, D6-DMSO): delta= 10.82 (br, IH), 8.05 (d, IH), 7.49 (d, IH), 7.42 (d, IH), 7.15 – 7.05 (m, 4H), 7.01 – 6.94 (m, 3H), 6.67 (s, IH), 4.37 (t, 2H), 3.93 (s, 3H), 3.05 (t, 2H), 2.16 (s, 3H)MS: M = 359.12 (ESI+)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1875-89-4, 2-(m-Tolyl)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2008/25526; (2008); A1;,
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