Aarsetoy, R; Ueland, T; Aukrust, P; Michelsen, AE; de la Fuente, RL; Ponitz, V; Brugger-Andersen, T; Grundt, H; Staines, H; Nilsen, DWT in [Aarsetoy, Reidun; Ponitz, Volker; Brugger-Andersen, Trygve; Nilsen, Dennis W. T.] Stavanger Univ Hosp, Dept Cardiol, POB 8100, N-4068 Stavanger, Norway; [Aarsetoy, Reidun; Grundt, Heidi; Nilsen, Dennis W. T.] Univ Bergen, Dept Clin Sci, Bergen, Norway; [Ueland, Thor; Aukrust, Pal; Michelsen, Annika E.] Oslo Univ Hosp, Res Inst Internal Med, Rikshosp, Oslo, Norway; [Aukrust, Pal] Oslo Univ Hosp, Sect Clin Immunol & Infect Dis, Rikshosp, Oslo, Norway; [de la Fuente, Ricardo Leon] Ctr Cardiovasc Salta, Salta, Argentina; [Grundt, Heidi] Stavanger Univ Hosp, Dept Resp Med, Stavanger, Norway; [Staines, Harry] Sigma Stat Serv, Balmullo, Scotland published Angiopoietin-2 and angiopoietin-like 4 protein provide prognostic information in patients with suspected acute coronary syndrome in , Cited 34. Category: alcohols-buliding-blocks. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5.
Background Plasma levels of angiopoietin-2 (ANGPT2) and angiopoietin-like 4 protein (ANGPTL4) reflect different pathophysiological aspects of cardiovascular disease. We evaluated their association with outcome in a hospitalized Norwegian patient cohort (n = 871) with suspected acute coronary syndrome (ACS) and validated our results in a similar Argentinean cohort (n = 982). Methods A cox regression model, adjusting for traditional cardiovascular risk factors, was fitted for ANGPT2 and ANGPTL4, respectively, with all-cause mortality and cardiac death within 24 months and all-cause mortality within 60 months as the dependent variables. Results At 24 months follow-up, 138 (15.8%) of the Norwegian and 119 (12.1%) of the Argentinian cohort had died, of which 86 and 66 deaths, respectively, were classified as cardiac. At 60 months, a total of 259 (29.7%) and 173 (17.6%) patients, respectively, had died. ANGPT2 was independently associated with all-cause mortality in both cohorts at 24 months [hazard ratio (HR) 1.27 (95% confidence interval (CI), 1.08-1.50) for Norway, and HR 1.57 (95% CI, 1.27-1.95) for Argentina], with similar results at 60 months [HR 1.19 (95% CI, 1.05-1.35) (Norway), and HR 1.56 (95% CI, 1.30-1.88) (Argentina)], and was also significantly associated with cardiac death [HR 1.51 (95% CI, 1.14-2.00)], in the Argentinean population. ANGPTL4 was significantly associated with all-cause mortality in the Argentinean cohort at 24 months [HR 1.39 (95% CI, 1.15-1.68)] and at 60 months [HR 1.43 (95% CI, 1.23-1.67)], enforcing trends in the Norwegian population. Conclusions ANGPT2 and ANGPTL4 were significantly associated with outcome in similar ACS patient cohorts recruited on two continents. Clinical Trial Registration ClinicalTrials.gov Identifier: NCT00521976. ClinicalTrials.gov Identifier: NCT01377402.
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