Month: February 2022

Adding a certain compound to certain chemical reactions, such as: 17102-63-5, 4-Bromo-2-methoxybenzyl alcohol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C8H9BrO2, blongs to alcohols-buliding-blocks compound. Computed Properties of C8H9BrO2

Step 2:; To the benzyl alcohol prepared in step 1 (0.86 g, 4.0 mmol) in DMF (8 mL) was added CuCN (1.1 g, 12 mmol). The mixture was warmed to 15O°C and stirred for 20 h. The mixture was then cooled to room temperature and EtOAc was added, followed by a saturated NH4CI/NH4OH solution. The mixture was stirred vigorously for 10 minutes and extracted with EtOAc, then the organic layer was dried (MgSO4), filtered, and concentrated in vacuo. Purification by silica gel chromatography provided 4-hydroxymethyl-3-methoxy-benzonitrile (0.38 g, 2.3 mmol).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,17102-63-5, 4-Bromo-2-methoxybenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Patent; SCHERING CORPORATION; WO2006/60461; (2006); A1;,
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Application of 59012-91-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.59012-91-8, name is 4-(Hydroxymethyl)phenyl pivalate, molecular formula is C12H16O3, molecular weight is 208.25, as common compound, the synthetic route is as follows.

Compound M2._:Compound Ml (see above; 7.79 g, 37.4 mmol) was dissolved in anhydrous THF (50 mL) containing Nu,Nu-diisopropylethylamine (8.14 mL, 46.8 mmol) under argon, and the resulting solution was chilled down to 0C in an ice-water bath. (0378) Diisopropylphosphoramidous dichloride (3.46 mL, 18.8 mmol) was added drop wise via syringe over a period of 5 minutes with stirring and cooling. The reaction mixture was allowed to warm up to room temperature and stirred overnight. Precipitated salts were removed by filtration, and the filtrate was concentrated in vacuum. The residue was dissolved in ethyl acetate (-150 mL) and washed with 5% NaHC03 (3 x 50 mL) followed by brine (50 mL). The organic layer was separated, dried over Na2S04, filtered and (0379) concentrated. The product (TLC: Rf~0.6 in ethyl acetate/hexanes/triethylamine (20:80:2)) was isolated using flash chromatography on silica gel column (4 x 20 cm) loading from hexanes/ triethylamine (100:2) and eluting with acetate/hexanes/ triethylamine (20:80:2). Pure fractions were pooled and concentrated to give 8.1 g (79%) of colorless oil. H NMR (DMSO-d6): delta 7.37 (d, 4H, J=8.6 Hz), 7.07 (d, 4H, J=8.6 Hz), 4.76 – 4.63 (m, 4H), 3.70 – 3.61 (m, 2H), 1.30 (s, 18H), 1.16 (d, 12H, J=6.8 Hz). 31P NMR (DMSO-d6): delta 147.30.

Statistics shows that 59012-91-8 is playing an increasingly important role. we look forward to future research findings about 4-(Hydroxymethyl)phenyl pivalate.

Reference:
Patent; CEPHEID; GALL, Alexander A.; LOKHOV, Sergey G.; PODYMINOGIN, Mikhail; VIAZOVKINA, Ekaterina V.; LUND, Kevin Patrick; WO2015/153496; (2015); A1;,
Alcohol – Wikipedia,
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Application of 17102-63-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17102-63-5, name is 4-Bromo-2-methoxybenzyl alcohol. A new synthetic method of this compound is introduced below.

A solution of anhydrous DMSO (5.1mL, 73mmol, 3.0equiv) in anhydrous dichloromethane (50mL) was cooled to ?78°C in a dry ice/i-PrOH bath. Oxalyl chloride (6.4mL, 73mmol, 3.0equiv) was added dropwise over 45min. The mixture was stirred for 15min and a solution of 4-bromo-2-methoxybenzyl alcohol (30b; 5.30g, 24mmol) in dichloromethane (10mL) was added dropwise. The resulting mixture was stirred for 30min at ?78°C. Triethylamine (12.4g, 120mmol, 5.0equiv) was then added, and the mixture was allowed to warm to rt over 16h. The mixture was quenched with water (100mL) and extracted with chloroform (3×200mL). The combined organic extracts were washed with water (1×150mL), brine (1×150mL), dried (MgSO4), filtered, and evaporated to yield the crude product as dark residue. The residue was purified by flash chromatography using chloroform to obtain an off-white solid that was recrystallized from hexanes to yield 3.73g (71percent) of the product as a white solid: Rf 0.18 (5percent EtOAc/hexane); mp 65?67°C; 1H NMR (CDCl3) delta 10.39 (s, 1H), 7.68 (d, 1H), 7.2?7.16 (m, 2H), 3.94 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17102-63-5, its application will become more common.

Reference:
Article; Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 419 – 434;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 28229-69-8, name is 3-Bromophenethyl alcohol. A new synthetic method of this compound is introduced below., Formula: C8H9BrO

Intermediate 56; 3-(2-Hydroxy-ethyl)-benzoic acid methyl ester; 2-(3-Bromo-phenyl)-ethanol (5.00 g, 24.87 mmol), 1 ,1′-bis(diphenylphosphino) ferrocene-palladium dichloride (0.70 g, 0.85 mmol) and triethylamine (7.00 g, 69.18 mmol) in MeOH (30 ml.) was heated at 90 0C (internal temperature) over a period of 10 h under carbon monoxide atmosphere (5 bar). After cooling to RT the solution was concentrated in vacuo and then partitioned between ethyl acetate and water. The organic layer was washed with brine and evaporated in vacuo. The crude product was purified by flash silica chromatography eluting with ethyl acetate//-hexane (1 :1).Yield: 3.3 g (74%).1H NMR (400 MHz, CDCI3): delta 7.93 – 7.90 (m, 2H), 7.44 (d, J = 7.2 Hz, 1 H),7.39 (t, J = 8.1 Hz, 1 H), 3.92 (s, 3H), 3.89 (t, J = 6.2 Hz, 2H), 2.93 (t, J = 6.4

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 28229-69-8, 3-Bromophenethyl alcohol.

Reference:
Patent; ARGENTA DISCOVERY LIMITED; ASTRAZENECA AB; WO2008/149110; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 431-23-2, name is 3,3,3-Trifluoro-2-methylpropan-1-ol, the common compound, a new synthetic route is introduced below. Recommanded Product: 431-23-2

Iodine (44.58 g, 175.6 mmol) was added in five portions to a stirring solution of (S*)-3,3,3-trifluoro-2-methylpropan-1-ol (15.0 g, 117 mmol, Intermediate 89), PPh3 (46.07 g, 175.6 mmol) and imidazole (11.96 g, 175.7 mmol) in NMP (75 mL) at a rate that maintained the internal temperature between 40 and 50 C. The mixture was then warmed to 55-60 C. and stirred until the reaction went to completion. The reaction mixture was then distilled directly to afford the title compound as a solution in NMP (50.5% w/w, bp 50-65 C. at 1-2 mm Hg).

The synthetic route of 431-23-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Janssen Pharmaceutica NV; Goldberg, Steven; Martin, Connor L.; Fennema, Elizabeth G.; Kummer, David A.; Nishimura, Rachel T.; Woods, Craig R.; Wolin, Ronald L.; Jones, William M.; Fourie, Anne M.; Xue, Xiaohua; (180 pag.)US2019/382349; (2019); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 57371-44-5, name is 3-(4-(Benzyloxy)-3-methoxyphenyl)propan-1-ol. A new synthetic method of this compound is introduced below., Formula: C17H20O3

General procedure: To an ice-cooled solution of 2-iodoxybenzoic acid (0.876 g, 3.129 mmol) in DMSO (1.11 mL, 15.64 mmol) was added a solution of alcohol 26a (0.59 g, 2.607 mmol) in dry CH2Cl2 (10 mL). The mixture was stirred at room temperature for 2 h and then filtered through a Celite pad and washed with ether. The combined organic filtrates were washed with water, brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/pet-ether, 1:9) to afford the pure compound 27a (0.508 g, 87%) as a viscous liquid. The unstable aldehyde used immediately for the next reaction.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 57371-44-5, 3-(4-(Benzyloxy)-3-methoxyphenyl)propan-1-ol.

Reference:
Article; Sabitha, Gowravaram; Srinivas, Chitti; Reddy, Teega Rammohan; Yadagiri, Kurra; Yadav, Jhillu Singh; Tetrahedron Asymmetry; vol. 22; 24; (2011); p. 2124 – 2133;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 14426-21-2, name is Diethanolamine hydrochloride. A new synthetic method of this compound is introduced below., SDS of cas: 14426-21-2

EXAMPLE 6 N,N-di-[2-(3,4,5-trimethoxybenzoyloxy)ethyl]taurine A mixture of 14 g of diethanolamine hydrochloride, 200 ml of dimethoxyethane and 47 g of 3,4,5-trimethoxybenzoyl chloride was left at ambient temperature for one night under agitation. The excess HCl was removed with a current of nitrogen, and the solution then evaporated under reduced pressure and taken up in 300 ml of anhydrous ethyl alcohol. 14 G of sodium ethoxide in 200 ml of absolute alcohol was added under cooling, then 21 g of sodium bromoethanesulphonate and 1.7 g of potassium iodide. After 120 hours at ambient temperature, the inorganic salts were filtered off and the solution concentrated under reduced pressure to a small volume. The mixture was then left to stand for one night, then filtered and crystallized from methanol. The product had a melting point of 179-182 C. and was identical to that obtained in Example 2.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 14426-21-2, Diethanolamine hydrochloride.

Reference:
Patent; Laboratorio Chimico Farmaceutico CAUSYTH S.p.A.; US4259332; (1981); A;,
Alcohol – Wikipedia,
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Synthetic Route of 81335-87-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 81335-87-7, name is (2-Amino-4-methylphenyl)methanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of but-2-ynoic acid (8 mmol, 1 equiv) and 2-aminobenzylalcohol (8 mmol, 1 equiv) in CH2Cl2 (60 mL) at 0 C was added a solution of N,N?-dicyclohexylcarbodiimide (DCC) (8 mmol, 1 equiv) in CH2Cl2 (20 mL) dropwise. The mixture was stirred at room temperature overnight, and then filtrated through a short pad of celite. The filtrate was concentrated and used for the next step without further purication. The crude solid was added to a suspension of pyridinium chlorochromate (PCC) (1.5-2.0equiv) and celite in CH2Cl2 (80 mL). The mixture was stirred at room temperature for 1-4 h, then filtrated and puried by silica gel column chromatography to give the product. The above crude solid was dissolved in THF (50 mL) and was added to a solution of NaH (1.3 equiv.) in THF (20 mL) dropwise at 0 C. The mixture was stirred at 0 C for half an hour, then MeI (1.3 equiv.) was added. The reaction mixture was stirred at room temperature until completion as monitored by TLC and then quenched by addition of saturated aqueous NH4Cl solution. The mixture was extracted with EtOAc, and the organic layer was washed with H2O and brine, dried over anhydrous Na2SO4, filtered, and concentrated under vacuum. The residue was puried by column chromatography on silica gel (eluent: ethyl acetate/petroleum ether = 1/4) to afford products 1b-1g.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 81335-87-7, (2-Amino-4-methylphenyl)methanol.

Reference:
Article; Zhang, Xiaojuan; Han, Xiuling; Chen, Junjie; Lu, Xiyan; Tetrahedron; vol. 73; 12; (2017); p. 1541 – 1550;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 175278-07-6, name is (2-(Trifluoromethoxy)phenyl)methanol, molecular formula is C8H7F3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C8H7F3O2

Example 5 Piperazine-1-carboxylic acid 2-trifluoromethoxy-benzyl ester hydrochloride was prepared from 2-trifluoromethoxy-benzyl alcohol; MS (ISP): 305.2 MH+.

With the rapid development of chemical substances, we look forward to future research findings about 175278-07-6.

Reference:
Patent; Adams, David Reginald; Bentley, Jonathan Mark; Davidson, James Edward Paul; Dawson, Claire Elizabeth; George, Ashley Roger; Mansell, Howard Langham; Mattei, Patrizio; Mizrahi, Jacques; Nettekoven, Matthias Heinrich; Pratt, Robert Mark; Roever, Stephan; Roffey, Jonathan Richard Anthony; Specklin, Jean-Luc; Stalder, Henri; Wilkinson, Kerry; US2002/143020; (2002); A1;,
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Application of 55357-38-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55357-38-5, name is 2-Hydroxy-N,N,N-trimethylethanaminium 4-methylbenzenesulfonate, molecular formula is C12H21NO4S, molecular weight is 275.3644, as common compound, the synthetic route is as follows.

EXAMPLE 9 A solution of 2.22 g of (E)-stigmasta-5,22-dien-3beta-yl (2-hydroxyethyl)carbonate and 1.1 ml of pyridine in 10 ml of chloroform is added dropwise to a solution, cooled to 0 C., of 0.75 g of phosphorus oxychloride in 3 ml of chloroform. The mixture is reacted at room temperature for 1 hour. Then, 1.6 g of choline tosylate in 15 ml of pyridine are added. The mixture is stirred overnight, then a solution of 2 g of potassium bicarbonate is added. The mixture is evaporated to dryness and the residue is taken up in 100 ml of THF/methanol/chloroform (1/1/1). The solids are filtered off. The solution remaining behind is percolated over an ion exchanger (Amberlite MB-3). After chromatography on silica gel with chloroform/methanol/water (60/35/5 vol) and crystallization from methylene chloride/acetone there are obtained 1.6 g of O-[hydroxy-[2-[[[(E)-stigmasta-5,22-dien-3beta-yloxy]carbonyl]oxy]ethoxy]phosphinyl]choline hydroxide internal salt, MS: 666 (M+H+).

The chemical industry reduces the impact on the environment during synthesis 55357-38-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hoffmann-La Roche Inc.; US5215972; (1993); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts