An article Highly Regioselective 5-endo-tet Cyclization of 3,4-Epoxy Amines into 3-Hydroxypyrrolidines Catalyzed by La(OTf)(3) WOS:000603407800001 published article about ENANTIOSELECTIVE AMINOLYSIS; PHARMACOLOGICAL-ACTIVITY; PYRROLIDINE DERIVATIVES; CYCLOPEPTIDE ALKALOIDS; 2,3-EPOXY ALCOHOLS; AEROBIC OXIDATION; ANTIFUNGAL AGENT; STEREOCHEMISTRY; ENTRY in [Kuriyama, Yuse; Sasano, Yusuke; Hoshino, Yoshihiko; Uesugi, Shun-ichiro; Yamaichi, Aoto; Iwabuchi, Yoshiharu] Tohoku Univ, Dept Organ Chem, Grad Sch Pharmaceut Sci, Aoba Ku, 6-3 Aoba, Sendai, Miyagi 9808578, Japan in 2021, Cited 38. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5. COA of Formula: C8H10O2
Highly regioselective intramolecular aminolysis of 3,4-epoxy amines has been achieved. Key features of this reaction are (1) chemoselective activation of epoxides in the presence of unprotected aliphatic amines in the same molecules by a La(OTf)(3) catalyst and (2) excellent regioselectivity for anti-Baldwin 5-endo-tet cyclization. This reaction affords 3-hydroxy-2-alkylpyrrolidines stereospecifically in high yields. DFT calculations revealed that the regioselectivity might be attributed to distortion energies of epoxy amine substrates. The use of this reaction was demonstrated by the first enantioselective synthesis of an antispasmodic agent prifinium bromide.
About (4-Methoxyphenyl)methanol, If you have any questions, you can contact Kuriyama, Y; Sasano, Y; Hoshino, Y; Uesugi, S; Yamaichi, A; Iwabuchi, Y or concate me.. COA of Formula: C8H10O2
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