Donthireddy, SNR; Pandey, VK; Rit, A in [Donthireddy, S. N. R.; Pandey, Vipin K.; Rit, Arnab] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India published [(PPh3)(2)NiCl2]-Catalyzed C-N Bond Formation Reaction via Borrowing Hydrogen Strategy: Access to Diverse Secondary Amines and Quinolines in 2021, Cited 57. Product Details of 105-13-5. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5.
Commercially available [(PPh3)(2)NiCl2] was found to be an efficient catalyst for the mono-N-alkylation of (hetero)aromatic amines, employing alcohols to deliver diverse secondary amines, including the drug intermediates chloropyramine (5b) and mepyramine (5c), in excellent yields (up to 97%) via the borrowing hydrogen strategy. This method shows a superior activity (TON up to 10000) with a broad substrate scope at a low catalyst loading of 1 mol % and a short reaction time. Further, this strategy is also successful in accessing various quinoline derivatives following the acceptorless dehydrogenation pathway.
Product Details of 105-13-5. About (4-Methoxyphenyl)methanol, If you have any questions, you can contact Donthireddy, SNR; Pandey, VK; Rit, A or concate me.
Reference:
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