Application In Synthesis of (4-Methoxyphenyl)methanol. Recently I am researching about BINDING MODE ANALYSIS; DIHYDROPYRIDINE DERIVATIVES; ANTIMOSQUITO PROPERTIES; MULTIDRUG-RESISTANT; LARVICIDAL ACTIVITY; INHA INHIBITORS; DESIGN; 1,4-DIHYDROPYRIDINES; POLYMORPHISM; DISCOVERY, Saw an article supported by the Deanship of Scientific Research, King Faisal University, Kingdom of Saudi Arabia [180128]. Published in BENTHAM SCIENCE PUBL LTD in SHARJAH ,Authors: Venugopala, KN; Deb, PK; Pillay, M; Chopra, D; Chandrashekharappa, S; Morsy, MA; Aldhubiab, BE; Attimarad, M; Nair, AB; Sreeharsha, N; Kandeel, M; Venugopala, R; Mohanlall, V. The CAS is 105-13-5. Through research, I have a further understanding and discovery of (4-Methoxyphenyl)methanol
Background: Tuberculosis remains one of the most deadly infectious diseases worldwide due to the emergence of multi-drug resistance (MDR) and extensively drug resistance (XDR) strains of Mycobacterium tuberculosis (MTB). Aims: Currently, available drugs are getting resistant and toxic. Hence, there is an urgent need for the development of potent molecules to treat tuberculosis. Materials and Methods: Herein, the screening of a total of eight symmetrical 1,4-dihydropyridine (1,4-DHP) derivatives (4a-4h) was carried out for whole-cell anti-TB activity against the susceptible H37Rv and MDR strains of MTB. Results and Discussion: Most of the compounds exhibited moderate to excellent activity against the susceptible H37Rv. Moreover, the most promising compound 4f (against H37Rv) having para-trifluoromethyl phenyl group at 4-position and bis para-methoxy benzyl ester group at 3- and 5-positions of 1,4- dihydropyridine pharmacophore, exhibited no toxicity, but demonstrated weak activity against MTB strains resistant to isoniazid and rifampicin. In light of the inhibitory profile of the title compounds, enoyl-acyl carrier protein reductase (InhA) appeared to be the appropriate molecular target. A docking study of these derivatives against InhA receptor revealed favorable binding interactions. Further, in silico predicted ADME properties of these compounds 4a-4h were found to be in the acceptable ranges, including satisfactory Lipinski’s rule of five, thereby indicating their potential as drug-like molecules. Conclusion: In particular, the 1,4-DHP derivative 4f can be considered an attractive lead molecule for further exploration and development of more potent anti-TB agents as InhA inhibitors.
Application In Synthesis of (4-Methoxyphenyl)methanol. About (4-Methoxyphenyl)methanol, If you have any questions, you can contact Venugopala, KN; Deb, PK; Pillay, M; Chopra, D; Chandrashekharappa, S; Morsy, MA; Aldhubiab, BE; Attimarad, M; Nair, AB; Sreeharsha, N; Kandeel, M; Venugopala, R; Mohanlall, V or concate me.
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