In 2021 SCI REP-UK published article about MANNOSE-BINDING LECTIN; IMMUNE COMPONENT FICOLIN-3; ALL-CAUSE MORTALITY; VASCULAR COMPLICATIONS; COMPLEMENT; ASSOCIATION; MICROALBUMINURIA; POPULATION; DEFICIENCY; SEVERITY in [Ostergaard, Jakob Appel] Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Aarhus, Denmark; [Ostergaard, Jakob Appel; Hansen, Troels Krarup] Aarhus Univ Hosp, Steno Diabet Ctr Aarhus, Aarhus, Denmark; [Sigfrids, Fanny Jansson; Forsblom, Carol; Dahlstrom, Emma H.; Thorn, Lena M.; Harjutsalo, Valma; Groop, Per-Henrik] Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland; [Sigfrids, Fanny Jansson; Forsblom, Carol; Dahlstrom, Emma H.; Thorn, Lena M.; Harjutsalo, Valma; Groop, Per-Henrik] Univ Helsinki, Nephrol, Abdominal Ctr, Helsinki, Finland; [Sigfrids, Fanny Jansson; Forsblom, Carol; Dahlstrom, Emma H.; Thorn, Lena M.; Harjutsalo, Valma; Groop, Per-Henrik] Helsinki Univ Hosp, Helsinki, Finland; [Sigfrids, Fanny Jansson; Forsblom, Carol; Dahlstrom, Emma H.; Thorn, Lena M.; Harjutsalo, Valma; Groop, Per-Henrik] Univ Helsinki, Res Program Clin & Mol Metab, Fac Med, Helsinki, Finland; [Thorn, Lena M.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland; [Harjutsalo, Valma] Natl Inst Hlth & Welf, Helsinki, Finland; [Flyvbjerg, Allan] Capital Reg Denmark, Steno Diabet Ctr Copenhagen, Copenhagen, Denmark; [Thiel, Steffen] Aarhus Univ, Dept Biomed, Aarhus, Denmark; [Groop, Per-Henrik] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia in 2021, Cited 39. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5. Product Details of 105-13-5
H-ficolin recognizes patterns on microorganisms and stressed cells and can activate the lectin pathway of the complement system. We aimed to assess H-ficolin in relation to the progression of diabetic kidney disease (DKD), all-cause mortality, diabetes-related mortality, and cardiovascular events. Event rates per 10-unit H-ficolin-increase were compared in an observational follow-up of 2,410 individuals with type 1 diabetes from the FinnDiane Study. DKD progression occurred in 400 individuals. The unadjusted hazard ratio (HR) for progression was 1.29 (1.18-1.40) and 1.16 (1.05-1.29) after adjustment for diabetes duration, sex, HbA(1c), systolic blood pressure, and smoking status. After adding triglycerides to the model, the HR decreased to 1.07 (0.97-1.18). In all, 486 individuals died, including 268 deaths of cardiovascular causes and 192 deaths of complications to diabetes. HRs for all-cause mortality and cardiovascular mortality were 1.13 (1.04-1.22) and 1.05 (0.93-1.17), respectively, in unadjusted analyses. These estimates lost statistical significance in adjusted models. However, the unadjusted HR for diabetes-related mortality was 1.19 (1.05-1.35) and 1.18 (1.02-1.37) with the most stringent adjustment level. Our results, therefore, indicate that H-ficolin predicts diabetes-related mortality, but neither all-cause mortality nor fatal/non-fatal cardiovascular events. Furthermore, H-ficolin is associated with DKD progression, however, not independently of the fully adjusted model.
About (4-Methoxyphenyl)methanol, If you have any questions, you can contact Ostergaard, JA; Sigfrids, FJ; Forsblom, C; Dahlstrom, EH; Thorn, LM; Harjutsalo, V; Flyvbjerg, A; Thiel, S; Hansen, TK; Groop, PH or concate me.. Product Details of 105-13-5
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