Month: September 2021

Related Products of 83647-43-2, Adding some certain compound to certain chemical reactions, such as: 83647-43-2, name is (3-Bromo-2-methylphenyl)methanol,molecular formula is C8H9BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83647-43-2.

Step B: 5-Bromo-4-methyl-2-benzofuran-l(3H)-one To a flask charged with (3-bromo-2-methylphenyl)methanol (6.0 g, 30 mmol) was added a 1M trifluoroacetic acid solution of thallium trifluoroacetate (16.2 g, 29.8 mmol). The mixture was stirred at RT overnight. The solvent was removed under vacuum, and the residue was pumped under high vacuum for 30 min to ensure complete removal of TFA. To the residue was then added palladium(II) chloride (529 mg, 2.98 mmol), lithium chloride (2.53 g, 59.7 mmol), magnesium oxide (2.41 g, 59.7 mmol), and methanol (150 mL). The reaction was flushed with CO twice, and kept under CO at room temperature. Analysis by LC showed a big product spot within 2 hours. To this solution was added ethyl acetate to precipitate the salts. The black solution was filtered through a diatomaceous earth pad, washed with EtOAc, adsorbed onto silica and purified by silica gel chromatography to afford 5-bromo-4-methyl-2-benzofuran-l(3H)-one. 1H-NMR (500 MHz, CDC13) delta ppm 7.71 (d, J= 8.0 Hz, 1H), 7.58 (d, J 2H), 2.37 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 83647-43-2, (3-Bromo-2-methylphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn; PASTERNAK, Alexander; CATO, Brian; FINKE, Paul, E.; FRIE, Jessica; FU, Qinghong; KIM, Dooseop; PIO, Barbara; SHAHRIPOUR, Aurash; SHI, Zhi-Cai; TANG, Haifeng; WO2013/39802; (2013); A1;,
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Electric Literature of 23147-58-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 23147-58-2, name is Glycerol aldehyde dimer. A new synthetic method of this compound is introduced below.

Compound I-ee was prepared using the method of Example 7. To a solution of compound I-ee (0.1 mmol) in methanol (1 mL) was added the aldehyde or ketone (0.2 mmol) and acetic acid (0.4 mmol), followed by sodium cyanoborohydride (0.2 mmol). The solution was stirred at 20 to 25 C (for reactive aldehydes) or 50 to 60 C (for less reactive aldehydes and ketones) until all of Compound I-ee was consumed. The reaction mixture was concentrated on a rotary evaporator, re-dissolved in a mixture of water-acetonitrile, filtered through a one-gram plug of C-18 silica gel, and purified by reversed-phase HPLC, eluted using a gradient of acetonitrile in water containing 0.1% acetic acid. The product was obtained as a white solid after lyophilization of desired fractions. EPO [00182] Compound I-nn (5S,6R)-5-[N-(2-hydroxyethyl)methylamino]polyangi-l ,6- diol) was synthesized using glycolaldehyde dimer at room temperature. ESI-TOF-MS m/z 518.3839, calcd for C31H52NO5 ([M + H]+) 518.3840.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23147-58-2, Glycerol aldehyde dimer, and friends who are interested can also refer to it.

Reference:
Patent; KOSAN BIOSCIENCES INCORPORATED; WO2006/66147; (2006); A2;,
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Synthetic Route of 1992-09-2, Adding some certain compound to certain chemical reactions, such as: 1992-09-2, name is 2-(4-Amino-3-methylphenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol,molecular formula is C10H9F6NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1992-09-2.

2.73 g of 2-(3′-methyl-4′-aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanolCompound of formula VAnd 4.89 g of cesium carbonate was added to the dried reaction flask,Add in 20 ml of DMF and stir at room temperature for 30 minutes.1.70 g of methyl iodide was slowly added to the reaction flask with a syringe,Stirring was continued at room temperature and TLC was detected until the conversion of the starting material was complete.After the reaction was completed, it was extracted with a saturated aqueous solution of ammonium chloride and ethyl acetate.The organic phase was dried over anhydrous sodium sulfate and dried under reduced pressure.The crude oily intermediate VIa was obtained for subsequent reaction.

According to the analysis of related databases, 1992-09-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; East China University of Science and Technology; Cao Song; Zhao Xianghu; He Jingjing; Li Jialu; Liu Yisen; Li Chunmei; Xu Sixue; Huang Qingchun; (19 pag.)CN110272361; (2019); A;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 558-42-9, name is 1-Chloro-2-methyl-2-propanol, the common compound, a new synthetic route is introduced below. Quality Control of 1-Chloro-2-methyl-2-propanol

EXAMPLE 1 Preparation of 2-(2-hydroxy-2-methylpropoxy)phenol from 1-chloro-2-methyl-2-propanol Catechol (11.0 g, 0.10 mole), sodium carbonate (10.6 g, 0.10 mole) and 100 g methanol were combined in a 250 ml 3-necked round bottom flask equipped with an air stirrer, heating mantle, condenser and thermometer, and heated to reflux (approximately 65° C.). 1-Chloro-2-methyl-2-propanol (10.9 g, 0.10 mole) was added by syringe. The mixture was refluxed for 3 hours, then left standing overnight. Water (40 ml) was added and the mixture was refluxed for 2 hours. After cooling, the water was extracted three times with 100 ml of dichloromethane. The combined dichloromethane layers were washed twice with 100 ml of water, then concentrated to afford 4.40 g (24percent) of waxy yellow solid. Recrystallization from ethyl acetate (10 g) and hexane (50 g) gave a white solid. 1 Hnmr analysis was consistent with the structural formula of 2-(2-hydroxy-2-methylpropoxy)phenol. Analysis: Cald., C 65.91percent, H, 7.74percent; found, C 65.85, 66.05, H 7.66, 7.66.

The synthetic route of 558-42-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Union Carbide Corporation; US4639536; (1987); A;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1072-52-2, name is 2-(Aziridin-1-yl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1072-52-2

Example 15 (Table 1, entry 8 and Scheme 11): Preparation of methyl 3-[(2-bromoethyl)- 2-[(methylsulfonyloxy)ethyl]amino]-2,6-dinitrobenzoate (27b); A solution of methyl 3- chloro-2,6-dinitrobenzoate (25) (1.15 g, 5.0 mmol) in dry DMF (10 mL) was treated with aziridineethanol (1.3 g, 15.0 mmol) and LiBr (4.35 g, 50 mmol)and stirred at room temperature for 6 h. The mixture was diluted with brine (40 mL) and extracted with EtOAc (2×60 mL). The combined organic fractions were washed with brine dried and concentrated under reduced pressure. Chromatography of the residue on silica gel, eluting with EtOAc/petroleum ether gave methyl 3-[(2-chloroethyl)(2-hydroxyethyl)amino]-2,6-dinitrobenzoate (26b) (0.40 g, 36% based on consumed starting material) as a yellow oil: 1H NMR [(CD3)2SO] delta 8.24 (d, / = 9.4 Hz, 1 H), 7.62 (dj = 9.4 Hz, 1 H), 4.79 (vbr s, 1 H), 3.78 (s, 3 H), 3.77 (t, / = 6.2 Hz, 2 H), 3.65 (t, / = 6.1 Hz, 2 H), 3.53 (t, / = 5.4 Hz, 2 H), 3.36 (t, / = 5.3 Hz, 2 H); 13C NMR delta163.2, 147.6, 136.4, 134.5, 128.1, 126.3, 121.9, 58.1, 53.8, 53.6, 52.5, 29.7. 38b: HRMS (FAB) calcd for C12H1579BrN3O7 [M+H]+ m/z 392.0093; found 392.0093.

With the rapid development of chemical substances, we look forward to future research findings about 1072-52-2.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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Synthetic Route of 18776-12-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.18776-12-0, name is 3-Chloro-1-phenylpropan-1-ol, molecular formula is C9H11ClO, molecular weight is 170.64, as common compound, the synthetic route is as follows.

To a solution of the 3-chloro-1-phenyl-propan-1-ol (1.5 g, 8.79 mmol) in DCM at 0 C. (50 mL) was added TEA (1.6 mL, 11.4 mmol) followed by MsCl (0.75 mL, 9.7 mmol). The reaction mixture was stirred 1.5 hours at 0 C., quenched with ice, and partitioned between a saturated solution of NaHCO3 and DCM. The organic layer was separated, washed with brine, dried over MgSO4, filtered, and concentrated at 0 C. The methanesulfonic acid 3-chloro-1-phenyl-propyl ester (95% crude yield, 2.08 g) thus prepared was used in the next step without purification.

The chemical industry reduces the impact on the environment during synthesis 18776-12-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Roche Palo Alto LLC; US2007/123535; (2007); A1;,
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Electric Literature of 4541-14-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4541-14-4, name is 4-(Benzyloxy)butan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

General Procedure P. A solution of the alcohol (1 equiv) in anhydrous CH2Cl2 (0.2 M) at 0 0C was treated with PCC (1.5 equiv) and the mixture was stirred for 45 min. The reaction mixture was allowed to warm at 25 C and stirred for 3 h. The suspension was filtered through Celite and concentrated. Column chromatography (SiO2) afforded the aldehyde.; 4-(Benzyloxy)butan-l-ol was oxidized to 4-(benzyloxy)butanal (7.35 g, 79%) following general procedure P

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4541-14-4, 4-(Benzyloxy)butan-1-ol.

Reference:
Patent; BOGER, Dale, L.; WO2008/150492; (2008); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5259-98-3, name is 5-Chloropentan-1-ol. A new synthetic method of this compound is introduced below., Application In Synthesis of 5-Chloropentan-1-ol

A solution of 5-chloro-l-pentanol (10 g, 80 mmol) in DMF (100 mL) at 0 0C was treated with imidazole (19 g, 185 mmol) and TBDPS-Cl (26 g, 95 mmol), and the mixture was stirred and allowed to warm to room temperature over 2 hours before being quenched with the addition of water and extracted with EtOAc. The organic extract was washed with aqueous IN HCl, saturated aqueous NaHCOs, saturated aqueous NaCl, dried (Na2SO4), concentrated under reduced pressure, and subjected to flash chromatography to give 5 -(t-butyldimethylsilyloxy)-l -chloropentane as a colorless liquid (11 g, 38percent).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5259-98-3, 5-Chloropentan-1-ol.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; VITAE PHARMACEUTICALS, INC.; WO2008/124575; (2008); A1;,
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Synthetic Route of 24131-31-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.24131-31-5, name is (3,5-Bis(benzyloxy)phenyl)methanol, molecular formula is C21H20O3, molecular weight is 320.3817, as common compound, the synthetic route is as follows.

General procedure: 3-Hydroxybenzaldehyde (5.00 g, 0.041 mol) was dissolved in anhydrous acetonitrile (130 mL) under argon atmosphere. Cesium carbonate (20.01 g, 0.061 mol) was added and the suspension stirred for 5 min. Benzyl bromide (11.69 mL, 0.102 mol) was then added and the solution heated at reflux for 16 h. The solution was concentrated on rotary evaporator, water was added and the mixture was extracted with EtOAc. The organic phase was washed twice with water, once with brine, dried over MgSO4, filtered and concentrated. Water was added and the mixture was extracted with CH2Cl2. The crude product was purified by flash chromatography on silica gel with hexanes/EtOAc (80/20) to yield 3a as a white solid (8.59 g). 1H NMR delta (CDCl3) 5.13 (s, 2H, PhCH2O), 5.33 (s, 2H, COOCH2Ph), 7.35-7.50 (m, 9H, 2-CH, 4-CH, 5-CH, 6-CH and PhCH2O), 10.00 (s, 1H, PhCHO). The aldehyde 3a was dissolved in anhydrous THF (200 mL) under argon and cooled to 0 C. Lithium aluminum hydride (1.55 g, 0.041 mol) was added in small portions and the solution stirred at room temperature for 2 h. The reaction was then quenched using water (0.8 mL), a 10% wt aqueous NaOH solution (1.15 mL) and water again (1.9 mL) and left to settle. The suspension was then filtered and concentrated. Water was added and the mixture extracted with EtOAc, the organic phase dried over MgSO4, filtered and concentrated to yield 7.07 g crude alcohol 3b. 1H NMR delta (CDCl3) 4.68 (s, 2H, PhCH2OH), 5.08 (s, 2H, PhCH2O), 6.90-7.46 (m, 9H, 2-CH, 4-CH, 5-CH, 6-CH and PhCH2O). Crude alcohol 3b (7.06 g) was dissolved in anhydrous CH2Cl2 (330 mL) and the solution cooled to 0 C. Triphenylphosphine (17.28 g, 0.066 mol) and carbon tetrabromide (21.85 g, 0.066 mol) were then added and the solution stirred at room temperature for 2 h. The reaction mixture was quenched with water and extracted with CH2Cl2. The organic phase was dried over MgSO4, filtered and concentrated. The product was purified by flash chromatography on silica gel with hexanes/EtOAc (9/1) to yield 5.85 g (64%) of bromide 3c.

Statistics shows that 24131-31-5 is playing an increasingly important role. we look forward to future research findings about (3,5-Bis(benzyloxy)phenyl)methanol.

Reference:
Article; Fournier, Diane; Poirier, Donald; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 4227 – 4237;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 148043-73-6, name is 4,4,5,5,5-Pentafluoropentan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4,4,5,5,5-Pentafluoropentan-1-ol

4,4,5,5,5-pentafluoropentanol (10 g) and methylene chloride (100 ml) is added to the reaction flask. Add triethylamine (11.3 g). Under ice bath, drop methanesulfonyl chloride (6.72 g). The completion of the dropping. Restoration to room temperature react for 2 hours. Water to wash the excess triethylamine and methyl chloride, dried with anhydrous sodium sulfate, turns on lathe does, get 14.14 g 4,4,5,5,5-pentafluoropentyl methanesulfonate.

With the rapid development of chemical substances, we look forward to future research findings about 148043-73-6.

Reference:
Patent; Tianjin Fuyin Biotechnology Development Co., Ltd.; Liu, Wenjuan; Mo, Lan; (9 pag.)CN104447447; (2017); B;,
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