Month: September 2021

Adding a certain compound to certain chemical reactions, such as: 558-42-9, 1-Chloro-2-methyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 558-42-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 558-42-9

A solution of 5 -fluoro-3 -nitropyridin-2( 1 H)-one (0.7058 g, 4.46 mmol), 1 -chloro2-methylpropan-2-ol (1.454 g, 13.39 mmol), potassium carbonate (1.234 g, 8.93 mmol) and sodium iodide (2.008 g, 13.39 mmol) in DMF (22.32 ml) in a pressure tube was heated to 125 °C and stirred overnight. LCMS showed ?1 :1 starting material:desiredproduct. The reaction was cooled to room temperature. EtOAc (150 mL) was added, and the solution was filtered through Celite®. The filtrate was washed with brine (40 mL), and the organic layer was dried over Na2SO4, filtered and concentrated in vacuo to give a residue which was purified by flash chromatography using an ISCO 80g column (solid loading) eluting with 20-100percent EtOAc/hexane. Appropriate fractions were collected andconcentrated in vacuo to give 5-fluoro-1-(2-hydroxy-2-methylpropyl)-3-nitropyridin-2(1H)-one (0.127 g, 0.497 mmol, 11.12 percentyield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,558-42-9, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; MOSLIN, Ryan M.; WEINSTEIN, David S.; TOKARSKI, John S.; WO2015/89143; (2015); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55489-58-2, name is 2-(2-(2-(Benzyloxy)ethoxy)ethoxy)ethanol, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

15-Bromo-1-phenyl-2,5,8,11-tetraoxapentadecane To a suspension of sodium hydride, 60% w/w in mineral oil (0.250 g, 6.24 mmol) in DMF (2 mL) was added a solution of 2-(2-(2-(benzyloxy)ethoxy)ethoxy)ethanol (1 g, 4.16 mmol) (Fluorochem) in DMF (2 mL) at 0 C. After stirring for 25 minutes, 1,4-dibromobutane (Aldrich) (4.04 g, 18.73 mmol) dissolved in DMF (2 mL) was added dropwise to the mixture. The reaction was stirred under an atmosphere of nitrogen for 2.5 hours. A further aliquot of sodium hydride, 60% w/w in mineral oil (0.250 g, 6.24 mmol) was added and the reaction was stirred at 0 C. for 30 minutes. The reaction was warmed to room temperature and stirred for 30 minutes. A final aliquot of sodium hydride, 60% w/w in mineral oil (0.250 g, 6.24 mmol), was added and the reaction stirred at room temperature for 2 hours then left standing over the weekend. The reaction mixture was filtered through celite and the solid washed with DCM. The filtrate was partitioned between DCM (30 mL) and water (30 mL). The organic extract was washed with brine (2*30 mL), dried using a hydrophobic frit and concentrated under reduced pressure. The product was purified by chromatography on silica using a gradient elution from 0% to 100% methyl tert-butyl ether in cyclohexane to afford the title compound (711 mg, 1.89 mmol, 46% yield). LCMS RT=1.16 min, ES+ve m/z 375.2/377.1 [M+H]+.

The synthetic route of 55489-58-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yale University; Arvinas, Inc.; Crew, Andrew; Crews, Craig; Dong, Hanqing; Ko, Eunhwa; Wang, Jing; (89 pag.)US2016/45607; (2016); A1;,
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Related Products of 768-95-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.768-95-6, name is Adamantan-1-ol, molecular formula is C10H16O, molecular weight is 152.23, as common compound, the synthetic route is as follows.

1-adamantanol (2 mmol) and catalytic amounts of the ionic liquid were charged into an oven-dried Schlenk tube under nitrogen, and the reaction mass was stirred for 15-20 minutes at r.t. To the resulting mixture the corresponding nitrile (1 mmol) was added, and the reaction mixture was stirred at the indicated temperature for the specified time (see Table 2). Progress of the reaction was monitored by TLC and GC-MS, after completion of reaction, the reaction mass was quenched with distilled water followed by neutralization with dilute NaHCO3 solution. The product was extracted in diethyl ether and dried over anhydrous MgSO4, the ether layer was evaporated in vacuum and the crude compound so obtained was chromatographed with hexane-ethyl acetate mixture(80:20) to afford pure colorless solids.

Statistics shows that 768-95-6 is playing an increasingly important role. we look forward to future research findings about Adamantan-1-ol.

Reference:
Article; Kalkhambkar, Rajesh G.; Waters, Sarah N.; Laali, Kenneth K.; Tetrahedron Letters; vol. 52; 8; (2011); p. 867 – 871;,
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Application of 39590-81-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 39590-81-3 as follows.

To a solution of (1-hydroxymethylcyclopropyl)methanol (1.02 g, 10 mmol) in DMF (20 mL),Add imidazole (1.36g, 20mmol) and cool to 0C.Add TBDPSCl (2.75 g, 10 mmol),The crude product was purified by column chromatography after 12 h of reaction to give compound 1-26 (2.046 g, yield 60%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39590-81-3, its application will become more common.

Reference:
Patent; Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.; Liu Gang; Yu Hua; Dong Zhenwen; Du Jing; Wang Runjiang; Liu Wei; Zeng Hong; Song Hongmei; Ge Yong; Wang Lichun; Wang Jingyi; (44 pag.)CN107814798; (2018); A;,
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Reference of 29055-08-1, Adding some certain compound to certain chemical reactions, such as: 29055-08-1, name is (2-(Methylamino)phenyl)methanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29055-08-1.

To a solution (50 [ML)] of [2- (methylamino) phenyl] methanol (1.37 g: synthesized according to the method described in WO 01/32652) in tetrahydrofuran were added pyridine (1.05 [ML),] acetic anhydride (1.23 [ML)] and 4-dimethylaminopyridine (0.18 g), and the mixture was stirred at room temperature for 8 hrs. Water (100 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate (100 mL). The organic layer was washed successively with a 5percent aqueous copper (II) sulfate solution (50 mL), a saturated aqueous sodium hydrogen carbonate solution (50 mL) and saturated brine (50 mL), and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was purified by flash silica gel column chromatography (eluted with ethyl acetate: hexane=1 : 5, then 1: 3) to give the title compound (0.38 g) as a white solid. [H-NMR] [(CDCL3)] [: 2.] 08 (3H, s), 2.87 (3H, s), 4.40 [(LH,] br), 5.08 (2H, s), 6.64-6. 74 (2H, m), 7.17-7. 32 (2H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29055-08-1, (2-(Methylamino)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2003/105845; (2003); A1;,
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Adding a certain compound to certain chemical reactions, such as: 29683-23-6, Tetrahydro-2H-thiopyran-4-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Tetrahydro-2H-thiopyran-4-ol, blongs to alcohols-buliding-blocks compound. Safety of Tetrahydro-2H-thiopyran-4-ol

Reference Example 1; 4- (4-bromo-3, 5-dimethylphenoxy) tetrahydro- 2H-thiopyranTo a solution of 4-bromo-3, 5-dimethylphenol (0.201 g, 1.00 mmol) , tetrahydro-2H-thiopyran-4-ol (0.130 g, 1.10 mmol) and triphenylphosphine (0.341 g, 1.30 mmol) in tetrahydrofuran (5 inL) was added diethyl azodicarboxylate (40% solution in toluene, 0.591 mL, 1.30 mmol), and the mixture was stirred at room temperature for 1.5 hr. Tetrahydro-2H-thiopyran-4-ol (0.0591 g, 0.500 mmol), triphenylphosphine (0.157 g, 0.600 mmol) and diethyl azodicarboxylate (40% solution in toluene, 0.272 mL, 0.600 mmol) were added, and the mixture was further stirred for 1.5 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate :hexane = 0:100 – 20:80) to give the title compound (0.261 g, yield 86%) as colorless crystals.1H NMR (CDCl3) delta: 1.93-2.07 (2H, m) , 2.10-2.23(2H, m) , 2.37(6H, s), 2.49-2.61(2H, m) , 2.85-2.98 (2H, m) , 4.26-4.35 (IH, m) , 6.65(2H, s) .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29683-23-6, Tetrahydro-2H-thiopyran-4-ol, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/1931; (2008); A2;,
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Application of 2240-88-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2240-88-2, name is 3,3,3-Trifluoropropan-1-ol, molecular formula is C3H5F3O, molecular weight is 114.07, as common compound, the synthetic route is as follows.

Example 98 (5a,8 )-8-Hydroxy-2-[4-(3,3,3-trifiuoro-propoxy)-phenyl]-2-aza-spiro[4.5]decan-l-oneStep 1: l-Nitro-4-(31313-trifluoro-propoxy)-benzeneTo a solution of a 3,3,3-trifiuoro-propan-l-ol (6.22 g) in acetonitrile (200 ml) kept at RT under an argon atmosphere were added l-fiuoro-4-nitro-benzene (10.1 g) and Cs2C03 (28.7 g) and the mixture was heated to 100°C for 18 h. The reaction mixture was cooled to RT and partitioned between AcOEt and ice water. The layers were separated, dried, over Na2S04 and the solvent was evaporated. The residue was purified by flash chromatography (silica gel; eluent: AcOEt/heptane: gradient 3 to 5 percent) to afford l-nitro-4-(3,3,3-trifiuoro- propoxy) -benzene as light yellow liquid (3.5 g). MS (EI, m/e): 235.0 (M+).

Statistics shows that 2240-88-2 is playing an increasingly important role. we look forward to future research findings about 3,3,3-Trifluoropropan-1-ol.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ACKERMANN, Jean; BRUGGER, Stephan; CONTE, Aurelia; HUNZIKER, Daniel; NEIDHART, Werner; NETTEKOVEN, Matthias; SCHULZ-GASCH, Tanja; WERTHEIMER, Stanley; WO2011/45292; (2011); A1;,
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Electric Literature of 162744-59-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.162744-59-4, name is (4-Bromo-2,6-difluorophenyl)methanol, molecular formula is C7H5BrF2O, molecular weight is 223.0148, as common compound, the synthetic route is as follows.

To a stirred solution of (4-bromo-2,6-difluoro-phenyl)methanol (4.2 g, 18.8 mmol) in CH2C12 (80 mL) at 0 C was added CBr4 (7.81 g, 23.5 mmol). After 5 min, a solution of triphenylphosphine (6.17 g, 23.5 mmol) in CH2C12 (20 mL) was added dropwise and the resulting mixture was stirred at room temperature for 2 hours. The mixture was concentrated in vacuo and the residue was taken up in heptane (100 mL). The resulting precipitate (white solid) was collected through a sintered glass and washed with further heptane. The filtrate was concentrated in vacuo to afford the title compound (6.90g, 78%) as a colorless oil which was used in the following step without further purification.

The chemical industry reduces the impact on the environment during synthesis 162744-59-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CECERE, Giuseppe; GALLEY, Guido; NORCROSS, Roger; PFLIEGER, Philippe; RAUBER, Etienne; (157 pag.)WO2016/30310; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 4720-29-0, 3-(Benzylamino)-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4720-29-0, blongs to alcohols-buliding-blocks compound. name: 3-(Benzylamino)-1-propanol

Step 1: Preparation of Intermediate 33A. Compound 1C (5.4 g) was stirred with 3-benzylaminopropanol (1.0 equiv) and anhydrous Na2SO4 (10 g) in THF for 30 min. Sodium triacetoxyborohydride (2.0 equiv) was added and the mixture was stirred at room temperature over night. The reaction was quenched with brine and extracted with ethyl acetate. The organic phase was dried over anhydrous Na2SO4 and evaporated to give crude Intermediate 33A (12.05 g) which was used without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4720-29-0, its application will become more common.

Reference:
Patent; CARA THERAPEUTICS, INC.; US2008/318935; (2008); A1;,
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Synthetic Route of 104-38-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.104-38-1, name is 1,4-Bis(2-hydroxyethoxy)benzene, molecular formula is C10H14O4, molecular weight is 198.2158, as common compound, the synthetic route is as follows.

General procedure: Chromonecarbonyl chloride was prepared by the reaction ofacid with thionyl chloride. After a toluene solution of 2-chromoniccarboxylic acid (1.4 g, 7.6 mmol) and thionyl chloride (1.1 g,9.1 mmol) was stirred at 90C for 2e3 h, thionyl chloride wasremoved under reduced pressure. The toluene solution of the cor-responding polyethers 4a-4c (0.5 g, 2.5 mmol) and chromone-carbonyl chloride was stirred at 120C overnight. After baseextraction, the solvent was removed under reduced pressure, andthe residue was separated by silica gel column chromatography(hexane/ethyl acetate) to obtain the corresponding chromone de-rivatives 5a-i in 30e92% yields.

Statistics shows that 104-38-1 is playing an increasingly important role. we look forward to future research findings about 1,4-Bis(2-hydroxyethoxy)benzene.

Reference:
Article; Ishikawa, Hiroki; Uemura, Naohiro; Taira, Ryo; Sano, Kento; Yoshida, Yasushi; Mino, Takashi; Kasashima, Yoshio; Sakamoto, Masami; Tetrahedron; vol. 75; 29; (2019); p. 3911 – 3916;,
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