Month: September 2021

Adding a certain compound to certain chemical reactions, such as: 57772-50-6, (2-Amino-3-methylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 57772-50-6, blongs to alcohols-buliding-blocks compound. SDS of cas: 57772-50-6

Imidazole (817 mg) and tert-butyldimethylsilyl chloride (1.09 g) were added to a solution of (2-amino-3-methyl-phenyl)-methanol (823 mg) in dimethylformamide (10 mL) at room temperature. The reaction mixture was stirred at room temperature for one hour, diluted with ethyl acetate and washed with a saturated sodium hydrogen carbonate aqueous solution and brine, dried over sodium sulfate and concentrated, and 1.51 g (100%) of the title compound was obtained as a colourless transparent oil. MS(FAB) m/z:252 (M + H)+.

The synthetic route of 57772-50-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sankyo Company, Limited; EP1764360; (2007); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.23147-58-2, name is Glycerol aldehyde dimer, molecular formula is C4H8O4, molecular weight is 120.1039, as common compound, the synthetic route is as follows.name: Glycerol aldehyde dimer

The compound (209.3 mg) obtained in Example 89-2 was dissolved in anhydrous methanol (8.4 ml). Then, the solution was added with [1,4]dioxan-2,5-diol (54.0 mg) and sodium cyanoborohydride (56.6 mg) and adjusted to pH 5 with acetic acid, followed by stirring at room temperature for 19.5 hours. After the reaction, the solvent was distilled off. Subsequently, the residue was added with a 1 mol/l sodium hydroxide aqueous solution (1.0 ml), followed by extraction with chloroform. The extract was dried with magnesium sulfate and the solvent was then distilled off. The residue was purified through silica gel column chromatography (chloroform/methanol) and then treated with hydrochloric acid, thereby obtaining hydrochloride (175.8 mg) of the subject compound as a white solid. MS(FAB,Pos.):m/z=510[M+H]+1H-NMR(500MHz,DMSO-d6+D2O):delta=0.92(6H,t,J=7.1Hz),1.64-1.68(6H,m),1.78-1.82(2H,m),3.00-3.08(10H,m),3.71(3H,s),3.74(4H,s),4.09(2H,s),4.17(2H,s),4.30 (2H,q,J=13.9Hz),7.41(2H,d,J=7.8Hz),7.48(4H,d,J=5.6Hz),7.61(2 H,s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,23147-58-2, Glycerol aldehyde dimer, and friends who are interested can also refer to it.

Reference:
Patent; Kureha Chemical Industry Co., Ltd.; EP1550657; (2005); A1;,
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Electric Literature of 202865-66-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 202865-66-5, name is (2-Bromo-5-fluorophenyl)methanol, molecular formula is C7H6BrFO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of (2-bromo-5-fluorophenyl) methanol (5g, 0.02 mol) in 1,4-dioxane (60 mL), bis(pinacolato)diboron (5.6 g, 0.022 mol) and potassium acetate (5.6 g, 0.06 mol) were added. The resulting mixture was degassed using a stream of nitrogen and to this was added [U’-bis(diphenylphosphino) ferrocene]dichloropalladium(ll) (250 mg, 0.34 mmol). The reaction mixture was then heated at 80 °C for 10 hrs. The mixture was cooled to room temperature, diluted with H20 and extracted with EtOAc. The organic layer was dried over Na2S04 and evaporated in vacuum to yield (5-fluoro-2-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)phenyl)methanol (5) that was used in the next reaction step without further purification. Yield-95percent; Purity-99.9percent.

According to the analysis of related databases, 202865-66-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOPHORE INDIA PHARMACEUTICALS PVT. LTD.; PULLAGURLA, Manik Reddy; NANDA KUMAR, Mecheril Valsan; PITTA, Bhaskar Reddy; RANGISETTY, Jagadeesh Babu; (55 pag.)WO2017/183043; (2017); A1;,
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Reference of 162358-05-6, Adding some certain compound to certain chemical reactions, such as: 162358-05-6, name is 2-(4-Octylphenyl)ethanol,molecular formula is C16H26O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 162358-05-6.

(1) 2-(4-Octylphenyl)ethyl iodide To a solution of 2-(4-octylphenyl)ethanol (25 g) in ether (200 ml)-acetonitrile (100 ml), imidazole (11 g) and triphenylphosphine (36 g) were added and the mixture was stirred at 0 C. for an hour. Iodine (38 g) was added to the solution and the whole mixture was stirred at 0 C. for 2 hours. Silica gel was added to the reaction solution and the mixture was filtered off. The precipitate was washed with a mixed solution of hexane-ethyl acetate (2:1). The filtrate and the solvent employed at washing were combined and concentrated. The residue was purified by silica gel chromatography (eluent; hexane-ethyl acetate=2:1) to give the subject compound (37 g). Rf value: 0.85 (hexane-ethyl acetate=4:1) MS: 344(M+) 1 H-NMR(400 MHz, CDCl3) delta: 0.88 (3H, t, J=8 Hz), 1.10-1.40 (10H, m), 1.50-1.65 (2H, m), 2.57 (2H, t, J=8 Hz), 3.14 (2H, t, J=8 Hz), 3.33 (2H, t, J=8 Hz), 7.09 (2H, d, J=8 Hz), 7.13 (2H, d, J=8 Hz)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 162358-05-6, 2-(4-Octylphenyl)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yoshitomi Pharmaceutical Industries, Ltd.; US5948820; (1999); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C8H11NO2

General procedure: The product S1 was dissolved in CHCl3. Then pyridine (1.2 equiv) and 4-toluenesulfonyl chloride (1.2 equiv) were added to the solution. The mixture was stirred at room temperature for 2 hours. After the reaction was completed, the reaction mixture was quenched with saturated ammonium chloride, and the mixture was extracted with ethyl acetate and dried over Na2SO4. After removal off the solvent, the crude product S2 was used directly without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 55414-72-7, (2-Amino-5-methoxyphenyl)methanol.

Reference:
Article; Sun, Bing-Bing; Hu, Qing-Xian; Hu, Jia-Ming; Yu, Jie-Qiang; Jia, Jun; Wang, Xing-Wang; Tetrahedron Letters; vol. 60; 30; (2019); p. 1967 – 1970;,
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Synthetic Route of 7250-55-7 ,Some common heterocyclic compound, 7250-55-7, molecular formula is C7H12O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of scheme 5-8 compound S1 (24 g, 0.136 mol) and benzyl 2,2,2-trichloroacetimidate (51.3 g, 0.204 mol) in cychexane/dichloromethane (600 mL/120 mL) at room temperature was added trifluoromethanesulfonic anhydride (cat.1.2 mL) dropwise. The reaction mixture was stirred at room temperature overnight and filtered. The filtrate was washed with sat. NaHCO3 and brine, dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by column chromatography on silica gel (eluted with petroleum ether: ethyl acetate =10: 1) to afford the title compound (35 g, 93.3% yield) as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7250-55-7, its application will become more common.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (508 pag.)WO2017/35409; (2017); A1;,
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Synthetic Route of 3973-18-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3973-18-0 as follows.

2-(Prop-2-ynyloxy)ethyl-lflr,l^,27/,2^-perfluorodecane-l-sulfonate (20); In a 25 mL round bottomed flask, distilled triethylamine (0.24 mL, 1.7 mmol) followed by lH,lH,2H,2H-perfluorodecane sulfonyl chloride (273 mg, 0.5 mmol) were added to a solution of 2-(prop-2-ynyloxy)ethanol (140 mg, 1.4 mmol) in DCM (3.0 mL) at 0C under a nitrogen atmosphere. The mixture was allowed to stir for 3 hours before being quenched with NaHCO3, extracted with DCM, and the organic phases dried over MgSO4. The solvent was removed under reduced pressure to give a crude solid product. Purification by column chromatography on silica gel (15% Et2O in hexane) afforded the target product as a white solid (71 mg, 0.12 mmol, 23% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3973-18-0, its application will become more common.

Reference:
Patent; ISIS INNOVATION LIMITED; GOUVERNEUR, Veronique; BEJOT, Romain; WO2010/7363; (2010); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7287-81-2, name is 1-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 7287-81-2

General procedure: A 10 mL Schlenk tube was charged with alcohol 3 (0.4 mmol), p-chlorophenyl hexanoate (3 equiv), Fe complex 2b (0.04 mmol), Me3NO (0.04 mmol), Novozym 435 (15 mg) and toluene (1 mL) under argon and stirred at 70 C for indicated time. After the reaction, the solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel to give the corresponding products, and the ee value was determined by GC or HPLC.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7287-81-2, 1-(m-Tolyl)ethanol.

Reference:
Article; Yang, Qiong; Zhang, Na; Liu, Mingke; Zhou, Shaolin; Tetrahedron Letters; vol. 58; 25; (2017); p. 2487 – 2489;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2516-33-8, name is Cyclopropylmethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2516-33-8

General procedure: To 259 mg (26.9 mmol) pyrimidin-5-ol (J. Chem. Soc. 1956, 2033) in 200 mL DMF are added 108 mg (26.9 mmol) sodium hydride (60% dispersion in mineral oil). The mixture is stirred for 20 mm at r.t.. After that time, 500 mg (22.4 mmol) 2-fluoro-4-iodopyridine are added and the mixture is stirred for 12 h at 80 C. Subsequently the mixture is poured into water and extracted with ethyl acetate (3x). The combined organic layers are washed with brine. After drying over sodium sulphate, the solvent is removed in vacuo and the residue is purified by column chromatography (silica gel; heptane/EtOAc, 100/0 – 40/60).C9H6IN3O (M = 299.1 g/mol)ESI-MS: 300 [M+H]+ Rt(HPLC) : 2.87 min (method C) For the example XXVIII.3 THF is used as solvent and the reaction mixture is stirred at r.t. over night.

With the rapid development of chemical substances, we look forward to future research findings about 2516-33-8.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; ROTH, Gerald Juergen; NOSSE, Bernd; HEINE, Niklas; WO2013/92616; (2013); A1;,
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