Month: September 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 28539-02-8, name is 1-(Hydroxymethyl)benzotriazole, the common compound, a new synthetic route is introduced below. category: alcohols-buliding-blocks

Example 439; 1-({trans-4-[({4-[2-(Difluoromethyl)-1H-benzimidazol-1-yl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl} amino)methyl]cyclohexyl}amino)-2-methylpropan-2-ol (100 mg) was dissolved in ethanol (2 mL), and triethylamine (31 mul) and 1H-benzotriazal-1-ylmethanol (82 mg) were added thereto, followed by stirring at room temperature for 2 hours. To the reaction mixture was added lithium borohydride (4.8 mg), followed by further stirring at room temperature for 1 hour. Water (10mL) was added thereto, followed by extraction with ethyl acetate (15 mL) and washing with saturated brine. The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by amino silica gel column chromatography (hexane:ethyl acetate=70:30) to obtain 4-[2-(difluoromethyl)-1H-benzimidazol-1-yl]-N-{[trans-4-(5,5-dimethyl-1,3-oxazolidin-3-yl)cyclohexyl]methyl}-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-amine (68 mg) as a white powder.

The synthetic route of 28539-02-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; EP2397479; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 83647-43-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 83647-43-2 as follows.

2-methyl-3-bromobenzyl alcohol (7 g, 34 mmol) was added to 120 mL of acetonitrile,NBS (6.8 g, 38 mmoL) was added at room temperature,The reaction was stirred at room temperature for 3 h,The solvent was removed by concentration under reduced pressure.To the residue was added 150 mL of dichloromethane,Stir,filter,The filtrate was concentrated under reduced pressure.The crude product was obtained by silica gel column chromatography (PE / EA = 85/15) to obtain 7.3 g (yield: 76.5%) of 2-methyl-3,6-dibromobenzyl alcohol;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,83647-43-2, its application will become more common.

Reference:
Patent; Chengdu Na Sheng Technology Co., Ltd.; Yan Gexin; Zhang Hui; Zhou Lihong; (15 pag.)CN106432214; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 68327-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride, molecular formula is C5H12ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 119Synthesis of (1S,2S)-2-(3-flupsilonorophenethylamino)cyclopentanol (XIII-I) trans-(1S, 2S)-2-Aminocyclopentanol hydrochloride (1.51 g, 0.011 mol) and triethylamine (Et3N, 1.32 g, 1.81 g, 0.013 mol), 3 A molecular sieves (3 g) were dissolved in dry DCE (30 mL). The mixture was stirred at room temperature under a N2 atmosphere for 10 min. NaBH(OAc)3 (2.76 g, 0.013 mol) and 1-4 (1.38 g, 0.01 mol) was then added, and the reaction mixture was stirred at room temperature under a N2 atmosphere overnight. NaOH (1 M, 20 mL) was then added, and the organic layer was separated. The aqueous layer was extracted with CH2Cl2 (20 mL x 2). The combined organic layers were washed with 1 M NaOH (20 mL) and H2O (20 mL), and then dried over Na2SO4. The solvent was concentrated in vacuo. The residue was purified by column chromatography (silica gel, CH2Cl2 : MeOH = 9.5 : 0.5) to afford a pale-yellow oil (1.38 g, 62%)

According to the analysis of related databases, 68327-04-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NORTHWESTERN UNIVERSITY; SILVERMAN, Richard, B.; JI, Haitao; LAWTON, Graham, R.; WO2008/42353; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 455-01-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.455-01-6, name is 2-(3-(Trifluoromethyl)phenyl)ethanol, molecular formula is C9H9F3O, molecular weight is 190.1624, as common compound, the synthetic route is as follows.

General procedure: To a mixture of caffeic acid fine powder (1.0 g, 5.56 mmol, 1.0 equiv.),alcohol (5.56 mmol, 1.0 equiv.) in nitromethane (125 mL) was addedytterbium triflate (34.4 mg, 0.056 mmol, 0.01 equiv.). After 5 min inan ultrasonic bath the mixture without protective gas was stirred ona 120 C oil bath for a given time. The reaction mixture was cooled toroom temperature, washed with deionised water (30 mL), 2% NaHCO3(30 mL) and brine, dried over anhydrous Na2SO4 and evaporated underreduced pressure to give the crude product, which was purified on asilica gel column to give the compounds 1-5 and 8-30.

The chemical industry reduces the impact on the environment during synthesis 455-01-6, I believe this compound will play a more active role in future production and life.

Reference:
Article; Xie, Dongsheng; Yang, Fengzhi; Xie, Jin; Zhang, Man; Liu, Wenlu; Fu, Lei; Journal of Chemical Research; vol. 38; 11; (2014); p. 695 – 700;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2568-33-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2568-33-4, name is 3-Methylbutane-1,3-diol. A new synthetic method of this compound is introduced below.

Step 1. Toluene-4-sulfonic acid 3-hydroxy-3-methyl-butyl ester 3-Methyl-1,3-butanediol (1.5 mL, 14.06 mmol) is suspended in dry dichloromethane (5 mL) and pyridine (1.24 mL, 15.46 mmol) is added followed by 4-toluenesulfonyl chloride (2.68 g, 14.06 mmol). The mixture is stirred overnight then washed with 1M aqueous hydrochloric acid, dried and the solvent removed under vacuum. The residue is purified by flash chromatography (0-30% ethyl acetate in cyclohexane) to give the title compound. (Yield 970 mg). LC (LC METHOD 4): tR=5.67 min; Mass spectrum (ES+): m/z=258 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2568-33-4, 3-Methylbutane-1,3-diol, and friends who are interested can also refer to it.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HAMPRECHT, Dieter; FRATTINI, Sara; LINGARD, Iain; PETERS, Stefan; US2013/324514; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 41175-50-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, molecular formula is C12H15NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To 15.0 mL anhydrous DMF was added dropwise POCl3 (0.9 mL, 9.2 mmol) under an atmosphere of argon at 0 C. The mixture was stirred at 0 C for 1h. A solution of compound 7 (1.6 g, 7.6 mmol) in anhydrous DMF (5.0 mL) was added in portions and then the reaction was allowed to be stirred at 0 C to room temperature for 32 h. Saturated salt solution (25 mL) was added and the reaction mixture extracted with EA. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The crude product was purified by column chromatography (PE:EA, 10:1) as a brown powder compound 8 (1.3 g, yield: 78.8%). 1H NMR (400 MHz, CDCl3), delta ppm: 9.42 (s, 1H), 7.30 (s, 1H), 6.89 (s, 1H), 3.33-3.32 (m, 4H), 2.72 (s, 4H), 1.98 (s, 4H); HRMS (ESI) calcd. for C13H16N1O2 [M+H]+: 218.1776, found 218.1208.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol.

Reference:
Article; Afzal, Muhammad Wasim; Chen, Xi; Gao, Ying; Guo, Yuan; James, Tony D.; Tang, Haoyang; Teng, Hao; Tian, Jingye; Zhang, Yanhui; Chinese Chemical Letters; (2020);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 756520-66-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 1-(2,6-Dichloro-3-fluorophenyl)ethanol

General procedure: 1-(2-chloro-5-fluorophenyl)ethan-1-ol (2.200 g, 12.6 mmol),triphenylphosphine (3.976 g, 15.1 mmol) and 5-bromo-2-nitropyridin-3-ol(2.755 g, 12.6 mmol) was dissolved in anhydrous THF(20 mL) and stirred for 30 minutes in an ice bath. The diisopropylazodiformate (3.057 g, 15.1 mmol) was added to the reaction solutionslowly at 0 oC and the mixture was stirred for4 h at room temperature. Then, the solution was concentrated with a rotaryevaporator. The crude product was purified by silica gelchromatography (petroleum ether/ethyl aceate = 100: 1, v/v) to obtain the titleproduct as white solid (4.232 g, 89.5 %).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,756520-66-8, its application will become more common.

Reference:
Article; Wang, Wanqi; Diao, Yanyan; Li, Wenjie; Luo, Yating; Yang, Tingyuan; Zhao, Yuyu; Qi, TianTian; Xu, Fangling; Ma, Xiangyu; Ge, Huan; Liang, Yingfan; Zhao, Zhenjiang; Liang, Xin; Wang, Rui; Zhu, Lili; Li, Honglin; Xu, Yufang; Bioorganic and Medicinal Chemistry Letters; vol. 29; 12; (2019); p. 1507 – 1513;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 13826-35-2, Adding some certain compound to certain chemical reactions, such as: 13826-35-2, name is (3-Phenoxyphenyl)methanol,molecular formula is C13H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13826-35-2.

To a solution of triphenyl phosphine (4.52 g; 17.2 mmol) and 3-phenoxybenzyl alcohol (3.44 g; 17.2 mmol) in THF (20 mL) kept in an ice bath was added a solution of 1a (4.61 g; 17.2 mmol) and diisopropyl azodicarboxylate (95%, 3.66 g; 17.2 mmol) in THF (20 mL). The reaction mixture was stirred at 0 C for 2 h and monitored by TLC. The solvent was removed on the rotary evaporator, leaving a yellow oil which was purified by flash chromatography (silica gel/ethyl acetate/hexane) to yield a white solid (6.33 g; 82% yield), mp 75-77 C. 1H NMR (CDCl3): delta 1.49 (s, 9H), 3.65 (d, 2H), 3.72 (s, 3H), 4.79 (s, 2H), 4.77 (t, J = 13.6 Hz, 1H), 6.90-7.03 (m, 4H), 7.10 (d, 2H), 7.30-7.39 (m, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13826-35-2, (3-Phenoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Dou, Dengfeng; Tiew, Kok-Chuan; Mandadapu, Sivakoteswara Rao; Gunnam, Mallikarjuna Reddy; Alliston, Kevin R.; Kim, Yunjeong; Chang, Kyeong-Ok; Groutas, William C.; Bioorganic and Medicinal Chemistry; vol. 20; 6; (2012); p. 2111 – 2118;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 5343-92-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5343-92-0, name is 1,2-Pentanediol, molecular formula is C5H12O2, molecular weight is 104.1476, as common compound, the synthetic route is as follows.

Prepare 55g sodium hydrogen (2.3mol) under nitrogen protectionAnd a suspension of 200 ml of tetrahydrofuran,Slowly add 1,2-pentanediol 125g (1.2mol) under micro refluxa mixture with 200 ml of tetrahydrofuran,There is a constant flow of gas to produce a discharge system.No gas is produced after stirring for 10 hours.A sodium salt suspension is obtained for use.After replacing the air in the 2000 mL autoclave with nitrogen,After adding 300 ml of tetrahydrofuran under nitrogen protection,Maintain internal temperature -10 ~ 0 C into the sulfuryl fluoride 151.6g (1.48 mol),The sodium salt suspension was continuously added to the kettle, and the reaction was kept for 2 hours.After the reaction, the nitrogen blowing system removes excess sulfuryl fluoride gas.The reaction solution was filtered and then decomposed to dryness under reduced pressure.The crude product was added with 300 ml of dichloromethane, 15-crown-5 0.1 g,18-crown-6 0.1g, refluxing for 1h,After filtration, the product was dried (162.7 g) (two-step yield 85.1%)

The chemical industry reduces the impact on the environment during synthesis 5343-92-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shanghai Kangpeng Technology Co., Ltd.; Quzhou Kangpeng Chemical Co., Ltd.; He Li; Li Xiaoliang; Tian Zhong; Yang Jianhua; (12 pag.)CN108409708; (2018); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 101597-25-5, name is 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol. A new synthetic method of this compound is introduced below., Recommanded Product: 101597-25-5

10244] A propargyl alcohol compound represented by thefollowing formula was provided. 10245] 1.55 Grams (4.0 mmols) of the indenonaphthol compound obtained in Example 4 and 1.40 g (5.2 mmols) of the above propargyl alcohol compound were dissolved in 47 ml of toluene and to which was, further, added 0.03 g of camphorsulfonic acid to conduct the reaction at 100 C. for one hour.10246] After the reaction, the solvent was removed, the reaction product was refined by chromatography (solvent chloroform) using silica gel and was, thrther, recrystallized with acetonitrile to obtain 1.86 g (2.9 mmols) of a white solid material of an indenonaphthopyran represented by the following formula (ES). The yield was 73%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 101597-25-5, 1,1-Bis(4-methoxyphenyl)prop-2-yn-1-ol.

Reference:
Patent; TOKUYAMA CORPORATION; IZUMI, Shinobu; TERANISHI, Kazuhiro; (26 pag.)US2016/130203; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts