Month: September 2021

Related Products of 623-04-1, Adding some certain compound to certain chemical reactions, such as: 623-04-1, name is (4-Aminophenyl)methanol,molecular formula is C7H9NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 623-04-1.

General procedure: To a solution of particular aromatic amine in 1,4-Dioxane (at the rate of 50 mg/ml) at -15.0 C, 5 equivalents of 2 M Sulphuric acid was added in small instalments while stirring. After 5 min 2 equivalents of 3 M sodium nitrite was added drop wise and after 30 min 3 equivalents of 3 M sodium azide was added drop wise carefully. Reaction was brought to room temperature and extracted with diethyl ether for at least three times. Organic layers were washed with saturated sodium bicarbonate solution two times, dried over anhydrous sodium sulphate and concentrated to a minimum volume under reduced pressure on Rotary evaporator without making use of heating from water bath.

According to the analysis of related databases, 623-04-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Farooq, Saleem; Shakeel-U-Rehman; Hussain, Aashiq; Hamid, Abid; Qurishi, Mushtaq A.; Koul, Surrinder; European Journal of Medicinal Chemistry; vol. 84; C; (2014); p. 545 – 554;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.928-92-7, name is 4-Hexen-1-ol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.Formula: C6H12O

trans-4-hexene-1-ol(16, 40.0 g, 0.4 mol) and Et3N (48.5 g, 0.48 mol) weredissolved in toluene 400 mL. MsCl (50.3 g, 0.44 mol) was then dropped into this solution,which was cooled with ice, keeping the reaction temperature at 25C or less. After agitatingfor 1 hr, brine 200 mL was added. The organic layer was washed twice using 5 wt%NaHCO3 solution 500 mL and water 500 mL. After drying with MgSO4, the toluene wasconcentrated. As a result, 4-hexene-1-mesylate (17, 69.5 g, 0.39 mol, yield: 97.5%) wasobtained as a colorless, oily substance.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,928-92-7, 4-Hexen-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Gotoh, Yasuyuki; Ushioda, Makoto; Molecular Crystals and Liquid Crystals; vol. 593; 1; (2014); p. 61 – 77;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 162358-05-6, name is 2-(4-Octylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(4-Octylphenyl)ethanol

Example 17 Preparation of 4-octylphenethyl methanesulfonate 2-(4-Octylphenyl)ethanol (53 g) and dichloromethane (500 mL) are charged into a 1 liter three-neck round bottom flask equipped with guard tube and addition funnel. Triethylamine (83.5 g) is added, the mixture is stirred for 30 minutes, then it is cooled to 0 C. Methanesulphonyl chloride (35.2 mL) is added drop-wise at 0 C. and the mass is stirred for 3 hours at room temperature. The mass is diluted with water (700 mL) and the organic layer is separated and the aqueous layer is extracted with dichloromethane (2*250 mL). The combined organic layers is washed with saturated sodium bicarbonate (500 mL) and brine solution (500 mL). The organic layer is separated, dried with sodium sulphate, and concentrated under vacuum to obtain the title compound. Yield: 70 g.

With the rapid development of chemical substances, we look forward to future research findings about 162358-05-6.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; Katkam, Srinivas; Sagyam, Rajeswar Reddy; Morthala, Raghavendar Rao; Ireni, Babu; Vinigari, Krishna; Ramdoss, Suresh Kumar; Rangineni, Srinivasulu; Tummala, Arjunkumar; Iqbal, Javed; Oruganti, Srinivas; Kandagatla, Bhaskar; US2014/235895; (2014); A1;,
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Electric Literature of 261762-59-8 ,Some common heterocyclic compound, 261762-59-8, molecular formula is C7H6ClFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of the compound of Reference Example 1 (100 mg, 0.32 mmol) in 1,4-dioxane (0.64 mL) was added (2-chloro-5-fluorophenyl) methanol (120 mg, 0.74 mmol), sodium hydride , 0.80 mmol) at room temperature, and the mixture was stirred at 100 C. for 48 hours. Water (10 mL) was added to the reaction mixture at room temperature and extracted with ethyl acetate (10 mL × 2). The organic layers were combined, dried over sodium sulfate and concentrated. The resulting concentrate was purified by silica gel column chromatography (eluent: ethyl acetate / n-hexane = 30/70) to give an intermediate as a yellow oil (80 mg).To a solution of the obtained intermediate (80 mg) in 1,4-dioxane (0.32 mL) was added 4 N hydrogen chloride 1,4-dioxane solution (0.8 mL) at room temperature, and the mixture was stirred at room temperature for 1 hour. Acetonitrile (5.0 mL) was added to the reaction mixture at room temperature, diethyl ether (1.5 mL) was added dropwise at room temperature, and the mixture was stirred at room temperature for 1 hour. The solid was collected by filtration and dried under reduced pressure at room temperature to give 1- (6 – ((2-chloro-5-fluorobenzyl) oxy) pyrazin-2-yl) -1, 4- diazepane dihydrochloride Compound of Example 8) as a white solid (40 mg, 31% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 261762-59-8, 2-Chloro-5-fluorobenzyl alcohol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TORAY INDUSTRIES INCORPORATED; KIKUCHI, TSUKASA; OKANO, TSUBASA; (24 pag.)JP2017/14121; (2017); A;,
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Electric Literature of 19812-64-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19812-64-7, name is Tetradecane-1,14-diol. A new synthetic method of this compound is introduced below.

Synthesis Example D-(25) 1,14-Tetradecandiol (1.5 g) was dissolved in 16.5 ml of cyclohexane, and 57% aqueous hydrobromic acid solution (16.5 ml) was added to this solution. The reaction mixture was refluxed for six hours while stirring. After the reaction, the mixture was extracted three times with diethyl ether. The organic layer was neutralized with saturated sodium hydrogen carbonate solution, washed with saline solution, dried over magnesium sulfate, and filtered, and the solvent was distilled off under reduced pressure. Purification of the residue by silica gel flash chromatography (hexane: ethyl acetate = 7:3) gave 14-bromotetradecan-1-ol as white crystals at a 67% yield. Molecular weight: 292.90 (C14H29BrO) TLC: (hexane-ethyl acetate 7-3) Rf value=0.53 1H-NMR: (300MHz, CDCl3) delta: 1.26 (s large, 20H, -(CH2)10-); 1.56 (qt, 2H, J=7.0Hz, -CH2-); 1.85 (qt, 2H, J=7.1Hz, -CH2-); 3.40 (t, 2H, J=6.9Hz, -CH2-Br); 3.64 (t, 2H, J=6.6Hz, -CH2-O-) 13C-NMR: (75MHz, CDCl3)delta: 25.72; 28.17; 28.75; 29.41-32.80; 32.82; 34.05; 63.08

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19812-64-7, Tetradecane-1,14-diol, and friends who are interested can also refer to it.

Reference:
Patent; Meiji Dairies Corporation; EP1854777; (2007); A1;,
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Application of 2979-22-8 ,Some common heterocyclic compound, 2979-22-8, molecular formula is C9H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of the appropriate alcohol (10mmol) in dry CH2Cl2 (20ml) was added Bu2SnO (0.2mmol) followed by the addition of pTsCl e (10mmol) and TEA (10mmol). The reaction mixture was kept under vigorous stirring at rt for 1-6h. The reaction mixture was quenched by adding water. The solution was extracted with dichloromethane and then combined organic phase were washed with a saturated aqueous solution of brine and dried over anhydrous Na2SO4. The solvent removing in vacuo give a residue that was crystallized or chromatographed to afford the desired compounds (1-5).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2979-22-8, its application will become more common.

Reference:
Article in Press; Pasquinucci, Lorella; Turnaturi, Rita; Prezzavento, Orazio; Arena, Emanuela; Arico, Giuseppina; Georgoussi, Zafiroula; Parenti, Rosalba; Cantarella, Giuseppina; Parenti, Carmela; Bioorganic and Medicinal Chemistry; (2017);,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16545-68-9, name is Cyclopropanol. A new synthetic method of this compound is introduced below., Safety of Cyclopropanol

To a solution of 1.5 g (7.44 mmol, 1.0 eq.) of 4-nitrophenyl chloroformate in 25 mL ofmethylene chloride at 0C was added 0.5 g (8.61 mmol, 1.16 eq.) of cyclopropanol followedby 0.63 g (8.05 mmol, 1.08 eq) of pyridine. The resulting solution was stirred at 0 C for 1.5 h. The mixture was diluted with 5 mL of methylene chloride and 10 mL of 0.1 M aqueous sulfuric acid. The organic phase was then washed with 10 mL of sat. NaHCO3, 10 mL of water and 10 mL of brine. The organic phase was dried (Na2SO4), filtered and concentratedto a volume of approximately 5 mL, and 10 mL of cyclohexane was added. The resulting yellow solid was removed, and the filtrate was evaporated to provide 0.8 g (3.58 mmol, 48%) of cyclopropyl (4-nitrophenyl) carbonate. ?H NMR (400 MHz, CDC13): 8.26-8.19 (m, 2H), 7.34-7.25 (m, 2H), 4.25-4.19 (m, 1H), 0.85-0.69 (m, 4H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16545-68-9, Cyclopropanol.

Reference:
Patent; ARBUTUS BIOPHARMA CORPORATION; COLE, Andrew, G.; DORSEY, Bruce, D.; KAKARLA, Ramesh; KULTGEN, Steven; QUINTERO, Jorge; (353 pag.)WO2018/172852; (2018); A1;,
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Related Products of 647-42-7 , The common heterocyclic compound, 647-42-7, name is 3,3,4,4,5,5,6,6,7,7,8,8,8-Tridecafluorooctan-1-ol, molecular formula is C8H5F13O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a stirred solution of the corresponding thiazoline 4a-c (2.0 mmol) in dry CH2Cl2 (8 mL) under N2 atmosphere at room temperature, were added subsequently the corresponding alcohol (2.0 mmol) EDCI (2.0 mmol) and catalytic amount of DMAP. After 16 h, the organic phase was transferred to an extraction funnel, washed with saturated NaHCO3 (2 × 10 mL), water (2 × 10 mL) and the organic layer was dried with Na2SO4. The solvent was evaporated and the remaining product was purified by chromatography (hexanes/AcOEt = 80:20).

The synthetic route of 647-42-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Schneider, Juliana M. F. M.; Sales, Eric S.; Livotto, Paolo R.; Schneider, Paulo H.; Merlo, Aloir A.; Journal of the Brazilian Chemical Society; vol. 25; 8; (2014); p. 1493 – 1503;,
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Related Products of 68327-04-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride, molecular formula is C5H12ClNO, molecular weight is 137.6079, as common compound, the synthetic route is as follows.

A solution of 128 mg intermediate 6-(4-chlorophenyl)-2-(1 -methyl-i H-pyrazol-4-yl)-3-oxo-2,3- dihydropyridazine-4-carboxylic acid (46%), 50 mg (1 S,2S)-2-aminocyclopentanol hydrochloride (1:1), 135 mg HATU, 0.13 mL ethyldiisopropylamine and 1 mg 4-dimethylaminopyridine in 1 mL of DMF was stirred at room temperature for 14 hours. Then the reaction mixture wasfiltered and subjected to RP-HPLC (instrument: Labomatic HD-3000 HPLC gradient pump, Labomatic Labocol Vario-2000 fraction collector; column: Chromatorex 0-18 125 mm x 30 mm, eluent A: 0.ivol% formic acid in water, eluent B: acetonitrile; gradient: A 70% I B 30% – A 30% I B 70%; flow: 150 mLlmin; UV-detection: 254 nm) to yield 3 mg 6-(4-chlorophenyl)-N- [(1 S ,2S)-2-hyd roxycyclopentyl]-2-(i -methyl-i H-pyrazol-4-yl)-3-oxo-2 ,3-d ihyd ropyridazine-4-carboxamide.1H NMR (400 MHz, DMSO-d6) 6 [ppm] = 1.38- 1.58 (m, 2 H), 1.60- 1.79 (m, 2 H), 1.80- 1.89(m, 1 H), 2.03 -2.18 (m, 1 H), 3.93 (s, 3 H), 3.94 – 3.99 (m, 1 H), 3.99 -4.07 (m, 1 H), 4.97 (d,1 H), 7.55 – 7.65 (m, 2 H), 8.07 – 8.14 (m, 3 H), 8.52 – 8.60 (m, 2 H), 9.44 (d, 1 H).

Statistics shows that 68327-04-8 is playing an increasingly important role. we look forward to future research findings about (1S,2S)-2-Aminocyclopentanol hydrochloride.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM; GUTCHER, Ilona; ROeHN, Ulrike; SCHMEES, Norbert; ZORN, Ludwig; ROeSE, Lars; BADER, Benjamin; KOBER, Christina; CARRETERO, Rafael; STOeCKIGT, Detlef; IRLBACHER, Horst; PLATTEN, Michael; (397 pag.)WO2018/146010; (2018); A1;,
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Reference of 5343-92-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5343-92-0, name is 1,2-Pentanediol, molecular formula is C5H12O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of 0.05 mol of acetal 1, 0.055 mol of diol 4a-4e, and 100 mg of toluenesulfonic acid in 50 mL of benzene was heated under reflux, while a fraction containing benzene and ethyl alcohol was distilled off. As distillate was distilled off, fresh solvent was added to the boiling solution. The distillation was carried out until the absence of ethanolin distillate according to gas-liquid chromatography.The reaction mixture was cooled, washed with NaHCO3 solution, dried with Na2SO4, benzene was removed, and the residue was distilled in a vacuum.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5343-92-0, 1,2-Pentanediol.

Reference:
Article; Zlotskii; Raskil?dina; Golovanov; Bormotin; Bekin; Doklady Chemistry; vol. 472; 1; (2017); p. 3 – 6; Dokl. Akad. Nauk; vol. 472; 1; (2017); p. 43 – 46,4;,
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