As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 34598-50-0, name is 5-Bromo-2,3-dihydro-1H-inden-1-ol, molecular formula is C9H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 5-Bromo-2,3-dihydro-1H-inden-1-ol
[001036] Part B. Preparation of l-azido-5-bromo-2,3-dihydro-lH-indene.; [001037] A solution of the product from Part A (l.Olg, 4.73mmol) in toluene (8.ImL) was treated with the diphenyl phosphoroyl azide (1.23mL, 1.56g, 5.67mmol) followed by cooling to O0C. The solution was treated dropwise with DBU (855muL, 863mg, 5.67mmol) followed by stirring at O0C for 2h, and then warming to room temperature for 48h. The mixture was diluted with ethyl acetate and extracted with water and 1 M citric acid solution, and then with saturated sodium chloride solution. Drying (Na2SO4) and concentration in vacuo afforded a brown oil, which was purified by flash chromatography, eluting with 5-50 % ethyl acetate in hexanes. These procedures afforded the title compound (889mg, 79%) as a light yellow oil.
With the rapid development of chemical substances, we look forward to future research findings about 34598-50-0.
Reference:
Patent; ABBOTT LABORATORIES; WO2009/39134; (2009); A1;,
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