Synthetic Route of 20017-67-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 20017-67-8, name is 3,3-Diphenyl-1-propanol. A new synthetic method of this compound is introduced below.
A solution (5 ML) of 1-(2-hydroxy-5-nitrophenyl)propan-1-one (500 mg, 2.56 mmol), 3,3-diphenylpropanol (765 mg, 3.84 mmol), 1,1-(azodicarbonyl)dipiperidine (969 mg, 3.84 mmol) and triphenylphosphine (1.01 g, 3.84 mmol) in toluene was stirred for 4 hours at 80C, and to the reaction solution were added 3,3-diphenylpropanol (765 mg, 3.84 mmol), 1,1-(azodicarbonyl)dipiperidine (969 mg, 3.84 mmol), triphenylphosphine (1.01 g, 3.84 mmol) and toluene (5 ML).. The mixture was stirred for 4 hours at 80C. To the reaction solution were further added 3,3-diphenylpropanol (765 mg, 3.84 mmol), 1,1-(azodicarbonyl)dipiperidine (967 mg, 3.84 mmol), triphenylphosphine (1.01 g, 3.84 mmol) and toluene (5 ML), and the mixture was stirred for 12 hours at 80C. The reaction solution was poured into water, and was extracted with ethyl acetate.. The extracted solution was washed with water, was dried with anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure.. The residue was purified by silicagel column chromatography (hexane:ethyl acetate = 20:1), to obtain the titled compound as oil. 600 mg (60.2%) 1H-NMR (CDCl3) delta; 1.23 (3H, t, J = 7.2 Hz), 2.58 – 2.69 (2H, m), 3.04 (2H, q, J = 7.2 Hz), 4.07 to 4.25 (3H, m), 6.87 (1 H, d, J = 9.0 Hz), 7.15 to 7.36 (10H, m), 8.24 (1H, dd, J = 9.0, 2.8 Hz), 8.55 (1H, d, J = 2.8Hz)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,20017-67-8, 3,3-Diphenyl-1-propanol, and friends who are interested can also refer to it.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1437344; (2004); A1;,
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