Synthetic Route of 22436-06-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 22436-06-2 as follows.
Under a nitrogen atmosphere, a 1 L three-necked glass vial was charged with 54 g of (±)-2-methyl-3-phenyl-1-propanol, 64 g of phthalic anhydride, 1.38 g of pyridine, and 540 g of tetrahydrofuran.The reaction was stirred at 0 C – 20 C for 30 hours, and concentrated to give a crude product (122 g).After crystallization with ethyl acetate as a solvent,103 g of (±)-2-methyl-3-phenyl-1-propanol-phthalic acid monoester were obtained, and the purity of the liquid chromatography was ?98%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,22436-06-2, its application will become more common.
Reference:
Patent; Jiangsu Guangyu Chemical Co., Ltd.; Diao Bozhen; Zhang Limeng; Kang Jie; (12 pag.)CN109503319; (2019); A;,
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