Electric Literature of 612-16-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 612-16-8, name is (2-Methoxyphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: The mixture of benzyl alcohol (1a, 0.3244 g, 3.0 mmol,1.5 equiv.), 2-aminopyridine (6a, 0.1882 g, 2.0 mmol), and NaOH (0.0400 g, 1.0 mmol, 50 mol%)was sealed under air in a 20 mL Schlenk tube and then stirred at 150 oC for 24 h. After completion,the reaction was monitored by TLC and/or GC-MS (>99% GC conversion) and the crude productwas purified by column chromatography using ethyl acetate and petroleum ether as eluent. Thetarget product 7a was obtained in 89% isolated yield. White solid. 1H NMR (500 MHz, CDCl3): delta 8.10 (dd,J = 5.0 Hz, J = 1.0 Hz, 1H), 7. 39-7.36 (m, 1H), 7.31 (d, J = 7.5 Hz, 1H), 7.26-7.23 (m, 1H),6.92-6.87 (m, 2H), 6.56-6.54 (m, 1H), 6.39 (d, J = 7.5 Hz, 1H), 5.01 (b, 1H), 4.48 (d, J = 6.0 Hz,2H), 3.85 (s, 3H). 13C NMR (125.4 MHz, CDCl3): delta 158.9, 157.4, 148.2, 137.3, 128.8, 128.3, 127.1,120.5, 112.8, 110.2, 106.7, 55.3, 41.7. MS (EI): m/z (%) 214 (60), 183 (92), 136 (45), 121 (35), 105(31), 91 (100), 78 (48), 65 (25), 51 (14).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 612-16-8, (2-Methoxyphenyl)methanol.
Reference:
Article; Li, Xiaohui; Li, Shuangyan; Li, Qiang; Dong, Xu; Li, Yang; Yu, Xiaochun; Xu, Qing; Tetrahedron; vol. 72; 2; (2016); p. 264 – 272;,
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