Application of 171011-37-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 171011-37-3, name is (4-Bromo-1,2-phenylene)dimethanol. A new synthetic method of this compound is introduced below.
Step 2: Synthesis of (5-bromo-2-(chloromethyl)phenyl)methanol A flask was charged with (4-bromo-1,2-phenylene)dimethanol (4.00 g, 18.4 mmol, 1.00 equiv) and hydrochloric acid (25 mL). The resulting solution was stirred for 15 min at 70 C and quenched with water (50 mL). The mixture was extracted with EtOAc (2 x 80 mL) and the organic layers were combined, dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was chromatographed on a silica gel column with EtOAc/petroleum ether (1/8) to provide 2.70 g (62% yield) of (5-bromo-2-(chloromethyl)phenyl)methanol as an off-white solid.1H NMR (300 MHz, DMSO-d6) ^ 7.64- 7.66 (m, 1H), 7.45- 7.49 (m, 1H), 7.36 (d, J = 8.1 Hz, 1H), 5.40- 5.45 (m, 1H), 4.78 (s, 2H), 4.66 (d, J = 4.5 Hz, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,171011-37-3, (4-Bromo-1,2-phenylene)dimethanol, and friends who are interested can also refer to it.
Reference:
Patent; ABIDE THERAPEUTICS, INC.; BUZARD, Daniel J.; SHAGHAFI, Michael B.; CISAR, Justin S.; GRICE, Cheryl A.; JONES, Todd K.; WEBER, Olivia D.; (277 pag.)WO2017/197192; (2017); A1;,
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