Electric Literature of 2615-15-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2615-15-8 as follows.
1005671 A solution of hexaethylene glycol (10 g, 35.46 mmol) in DCM (100 mL) was charged with Ag20 (12.34 g, 53.19 mmol), KI (1.17 g, 7.04 mmol) and stirred at room temperature for 15 mm. This solution was charged with tosyl chloride (7.35 g, 38.68 mmol)and stirred at room temperature for 6 h. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 2% methanol in DCM to give 8.80 g, 57% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.78 (d, J= 7.9 Hz, 2H), 7.48 (d, J= 7.7 Hz, 2H), 4.56 (t, J= 5.4 Hz, 1H), 4.11 (t, J= 4.3 Hz, 2H), 3.563.32 (m, 22H), 2.42 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2615-15-8, its application will become more common.
Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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