Adding a certain compound to certain chemical reactions, such as: 455-01-6, 2-(3-(Trifluoromethyl)phenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H9F3O, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C9H9F3O
General procedure: To a stirred solution of betulonic acid (3, 0.883 g, 1.94 mmol) in anhydrous CH2Cl2 (10 mL) was added oxylchoride (1.70 mL,19.45 mmol) at rt and kept for 2 h. The solvent was removed under vaccum, and another 3 mL CH2Cl2 was added to the residue and then removed again. To the residue was added anhydrous CH2Cl2 (8 mL), 2-cyclopropylethanol (0.5025 g, 5.83 mmol) and triethyl amine (2.71mL, 19.44 mmol), and the mixture was stirred for 24 h at rt. After removal of solvent under vaccumn, the residue was purified by silica gel column chromatography (hexane/EtOAcas eluent) to provide desired compound 10 (760 mg). White solid, yield 75%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,455-01-6, 2-(3-(Trifluoromethyl)phenyl)ethanol, and friends who are interested can also refer to it.
Reference:
Article; Li, Jizhen; Goto, Masuo; Yang, Xiaoming; Morris-Natschke, Susan L.; Huang, Li; Chen, Chin-Ho; Lee, Kuo-Hsiung; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 68 – 71;,
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