Synthetic Route of 68327-04-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride, molecular formula is C5H12ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Examples of Synthesis of Carboxamides from Diketoacid Precursor; Representative Example 1; (l S,2S)-4-(5-(2,4-difluorobenzyl)-l -(2-fluorobenzyl)-2-oxo-l,2-dihydropyridin-3-yl)-2- hydroxy-N-(2-hydroxycyclopentyl)-4-oxobut-2-enamide (9).; To a chilled solution of the 4-(l-(2-fluorobenzyl)-5-(4-fluorobenzyl)-2-oxo-l ,2- dihydropyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic acid 8 (150 mg, 0.338 mmol) indimethyl formamide (DMF) (2.0 mL), was added hydroxybenzotriazole (HOBT) (50 mg, 0.372 mmol), followed by l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride EDCI-HCl (71 mg, 0.372 mmol). The resulting mixture was stirred for 30 min. A solution of ( l S,2S)-(+)-trans-2-aminocyclopentanol hydrochloride and NaHC03 (31 mg, 0.372 mmol) was added. The resulting mixture was stirred for 2h at 0- 5 C. Thin layer chromatography 05918344(TLC) analysis indicated completion, hence cold water was added to the reaction mixture and then extracted with ethyl acetate (2 x 20 m L). The combined organic phase was separated and washed with water twice, then once with IN HC1 solution, then saturated aqueous NaHCO.? solution. Concentration in vacuo afforded the crude product which was passed through a short plug of silica gel eluting with chloroform, the eluent was concentrated and the residual triturated with hexanes affording the product as a yellow solid in 117 mg (66.0%). The residual solvent was removed in vacuo affording pure product as a yellow solid, mp 60.0- 62.9 C, [a]20D +24.0 (c 0.01, MeOH}. UV (MeOH) 396 nm (epsilon 14,455), 318 nm (epsilon 6327). NMR (CDCI3, 500 MHz): delta 15.33 (bs, IH), 8.16 (d, IH, J= 2.0Hz), 8.08 (s, 111), 7.61-6.85 (m, 9Eta), 5.22 (s, 2Eta), 4.11 (m, IH), 3.94 (m, IH), 3.78 (s, IH), 2.23 (m. III).2.10 (m, IH), 1.88 (m, IH), 1.78 (m, 211).1.59 (m, IH).13C NMR (CDCI3, 125 MHz): delta 181.3, 180.6, 163.4, 163.3, 162.4, 162.1, 162.0, 161.4, 161.3, 160.4, 160.1, 160.0, 159.2, 145.5, 143.9, 142.3, 141.6, 132.4.1 2.4.132.3, 131.5.131.4, 131.3, 131.3, 131.2, 130.7, 130.6, 125.0, 124.9, 124.8, 122.8, 122.7, 122.5, 122.2.122.2, 122.1, 122.1.117.1, 115.9, 115.7, 115.6, 111.9, 111.9, 111.8, 111.7, 104.7, 104.5, 104.3,98.3,79.5,79.3,61.0,60.6,51.5,47.7,47.3, 32.9, 32.8, 32.7, 30.8, 30.7, 30.5, 21.7, 21.5. HRMS (M+H)+ calculated mass 527.1794 for C28H26F3N2O5, found 527.1799.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 68327-04-8, (1S,2S)-2-Aminocyclopentanol hydrochloride.
Reference:
Patent; UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.; NAIR, Vasu; OKELLO, Maurice, O.; NISHONOV, Abdumalik, A.; MISHRA, Sanjaykumar; WO2011/71849; (2011); A2;,
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