Sep-21 News New downstream synthetic route of 3973-18-0

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3973-18-0, Propynol ethoxylate, and friends who are interested can also refer to it.

Synthetic Route of 3973-18-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3973-18-0, name is Propynol ethoxylate. A new synthetic method of this compound is introduced below.

Preparation of 2-(prop-2-yn-l-yloxy)ethyl trifluoromethanesulfonate 4. To a solution of 2-(prop-2-yn-l-yloxy)ethanol (3) (1.50 g, 15.0 mmol) in (( (20 mL) was added 2,6-lutidine (2.44 mL, 21.0 mmol) followed by trifluoromethanesulfonic anhydride (3.15 mL, 18.7 mmol) at -50 C under argon atmosphere. The mixture was stirred at -10 C for 2 h. It was then partitioned between 50% EtOAc in hexanes (150 mL) and brine (15 mL). The organic layer was separated, washed with brine (15 mL) and dried over anhydrous MgS04. The insoluble was filtered and the filtrate was evaporated in vacuo. The crude material was purified by silica gel column chromatography (silica gel: 50 g, solvent 10% EtOAc in hexanes (500 mL)). The desired fractions were combined and evaporated in vacuo to give the titled compound (2.49 g, 72%) as a dark brown oil. This material was used for the next reaction without further purification. [0313] ln NMR (400 MHz, CDC13) delta 4.64-4.66 (2H, m), 4.22^1.25 (2H, m), 3.85-3.88 (2H, m), 2.48-2.49 (1H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3973-18-0, Propynol ethoxylate, and friends who are interested can also refer to it.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; SHOKAT, Kevan; OKANIWA, Masanori; (209 pag.)WO2016/40806; (2016); A1;,
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