Reference of 4654-39-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Reference Example 2 2-(4-bromophenyl)ethyl iodide To a solution of 2-(4-bromophenyl)ethanol(75.0 g) and triethylamine (45.3 g) in methylene chloride (400 mL) was added dropwise methanesulfonyl chloride (47.0 g) at 0C over 1 hr, and the mixture was stirred at the same temperature for 3 hr. The reaction mixture was poured into ice water, and the organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure. To a solution of the residue in methyl ethyl ketone (500 mL) was added sodium iodide (67.1 g), and the mixture was stirred at 90C for 3 hr. The reaction mixture was concentrated under reduced pressure, and water (500 mL) was added to the residue. After extraction with ethyl acetate, the mixture was washed with 1% aqueous sodium thiosulfate solution and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (116 g) as brown crystals. 1H-NMR(CDCl3)delta(ppm): 3.13(2H, t, J=7.7Hz), 3.32(2H, d, J=7.4Hz), 7.07(2H, d, J=8.4Hz), 7.44(2H, d, J=8.1Hz).
According to the analysis of related databases, 4654-39-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; EP2017257; (2009); A1;,
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