Related Products of 52059-53-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52059-53-7, name is 2-(3-Fluorophenyl)ethanol, molecular formula is C8H9FO, molecular weight is 140.1549, as common compound, the synthetic route is as follows.
To a solution of (S)-isopropyl 2-(2-amino-4-(4,4-dimethylpiperidin- 1 -yl)-5 ?,6?-difluoro-6-methyl- [3,3 ?-bipyridinj -5 -yl)-2-(tert-butoxy)acetate (0.042 g, 0.059 mmol, 1 equiv) and 2-(3-fluorophenyl)ethanol (0.042 g, 0.297 mmol, 5 equiv) in THF (1.5 mL)was added 60% NaH (0.012 g, 0.297 mmol, 5 equiv). The reaction was heated at 60 C for 1 h. EtOH (0.9 mL) and 10 N NaOH (0.1 mL) were added and the temperature was raised to 80 C for 4 h. After cooling to ambient temperature, the reaction was filtered. The cmde mixture was purified by preparative LC/MS to provide the product (9 mg, 26%). ?H NMR (500 MHz, DMSO-d6) 7.89 – 7.44 (m, 2H), 7.38 – 7.32 (m, 1H), 7.17 -7.10 (m, 2H), 7.07 -7.00 (m, 1H), 5.70 (s, 1H), 5.09 (br s, 1H), 4.75 -4.53 (m, 2H), 3.18- 3.02 (m, 2H), 2.91 – 2.64 (m, 1H), 2.32 (s, 3H), 1.60 – 1.43 (m, 1H), 1.26 (s, 2H), 1.16 (s, 9H), 1.09 – 0.98 (m, 1H), 0.86 (br s, 3H), 0.62 (br s, 3H) [note: appears to be a 60:40 mixture ofrotamers around pyridine pyridine biaryl bond, piperidine protons are broad and not all visiblej. LCMS (M+1) = 583.3.
Statistics shows that 52059-53-7 is playing an increasingly important role. we look forward to future research findings about 2-(3-Fluorophenyl)ethanol.
Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; BELEMA, Makonen; BOWSHER, Michael S.; DESKUS, Jeffrey A; EASTMAN, Kyle J.; GILLIS, Eric P; FRENNESSON, David B; IWUAGWU, Christiana; KADOW, John F.; NAIDU, B. Narasimhulu; PARCELLA, Kyle E.; PEESE, Kevin M; SAULNIER, Mark G; SIVAPRAKASAM, Prasanna; (463 pag.)WO2018/127800; (2018); A1;,
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