Application of 349-75-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 349-75-7, name is (3-(Trifluoromethyl)phenyl)methanol, molecular formula is C8H7F3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation No.23: Synthesis of 2-Fluoro-4-(3-(trifluoromethyl)benzyloxy)benzonitrile; In a 1 L round-bottomed flask, DIAD (14.31 mL, 72.7 mmol) and tnphenylphosphme (19.07 g, 72 7 mmol) m THF (200 mL) were stirred for about 5 mm under nitrogen and cooled to about 0 C. 2-Fluoro-4-hydroxybenzonitrile (6.65 g, 48.5 mmol) was added to give a dark orange solution. The mixture was stirred about an additional 5 mm and then 3-(t?fluoromethyl)benzyl alcohol (7.26 mL, 53 3 mmol) m THF (50 mL) was added. The mixture was stirred overnight at ambient temperature then evapoiated to dryness. The solid was purified on a Combiflash Companion XL system using a 330 g Redi-Sep silica gel column using the following gradient: A: Heptane; B: Ethyl acetate, 10 to 100 %B over 7 column volumes. NMR indicated the presence of t?phenyl phosphme oxide and reduced DIAD. The iesidue was triturated with light petroleum ether (250 mL) for 1 hour, filtered and the solid dried under vacuum overnight. This gave 2-fluoro-4-(3- (t?fluoromethyl)benzyloxy)benzomt?le (9.31 g, 31.2 mmol, 99%). 1H NMR (400 MHz, DMSO- Cl6): delta 7.91 – 7.83 (m, 2H), 7 78 (d, J = 7.7, IH), 7.74 (d, J = 7.8, IH), 7.66 (t, J = 7.7, IH), 7.30 (dd, J = 2.4, 11.9, IH), 7.09 (dd, J = 2.4, 8.8, IH), 5.34 (s, 2H). (Table 2, Method b) Rt = 1.60 mm; MS m/z: 294.04 (M-H) .
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 349-75-7, (3-(Trifluoromethyl)phenyl)methanol.
Reference:
Patent; ABBOTT LABORATORIES; HARRIS, Christopher, M.; HOBSON, Adrian, D.; WILSON, Noel, S.; WO2010/93704; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts