As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65735-71-9, name is (4-Chloro-3-(trifluoromethyl)phenyl)methanol, molecular formula is C8H6ClF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 65735-71-9
Step A: Preparation of l-Chloro-4-(chloromethyl)-2-(trifluoromethyl)benzene.(4-Chloro-3-(tpifluoromethyl)phenyl)methanol (5.1 g, 24.22 mmol) was added m small portions to thionyl chlopide (20 mL, 275 mmol). The reaction mixture was stirred at 50 0C for 18 h and heated under reflux for 23 h. The mixture was concentrated and dried under high vacuum to give the title compound as a colorless liquid (5.41 g). 1H NMR (400 MHz, CDCl3) delta ppm 4.58 (s, 2H), 7.50-7.5 l(m, 2H), 7.71 (s, IH).
With the rapid development of chemical substances, we look forward to future research findings about 65735-71-9.
Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; BUZARD, DAniel J.; HAN, Sangdon; KIM, Sun He; LEHMANN, Juerg; ULLMAN, Brett; MOODY, Jeanne V.; ZHU, Xiuwen; STIRN, Scott; WO2010/11316; (2010); A1;,
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