Reference of 41175-50-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol. A new synthetic method of this compound is introduced below.
Under Argon, fresh distilled DMF (2.8 mL) was added dropwise toPOCl3 (2.8 mL) at room temperature and stirred for 30 min to yield ared solution. Then a portion of 2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-ol (3.15 g, 16.64 mmol, dissolved in 10 mL DMF) wasadded dropwise to the above solution and a scarlet suspension wasyielded. The mixture was stirred at room temperature for 30 min and80 C for 30 min until the reaction was completed, then the reactionmixture was poured into 150 mL of ice water. NaOH solution (20%)was added to adjust the pH to 6 and continue stirred for 2 h, and alarge amount of precipitate was obtained. The crude product was purifiedby flash column chromatography (PE:EA = 20:1, v/v) to give theproduct as a brown solid (2.50 g, yield: 69.1%). 1H NMR (500 MHz,CDCl3) delta 11.80 (s, 1H), 9.36 (s, 1H), 6.82 (s, 1H), 3.27 (m, 4H), 2.66 (t,J = 6.4, 6.4 Hz, 4H), 1.92 (q, J = 6.0, 6.0, 5.9 Hz, 4H). 13C NMR(126 MHz, CDCl3) delta 191.66, 159.41, 149.58, 131.25, 113.68, 110.75,105.35, 50.40, 50.04, 27.32, 21.77, 20.68, 19.75.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,41175-50-2, its application will become more common.
Reference:
Article; Gan, Yabing; Li, Haitao; Liu, Meiling; Yao, Shouzhuo; Yin, Guoxing; Yin, Peng; Yu, Ting; Zhang, Youyu; Zhou, Li; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 241; (2020);,
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